Several intriguing conference matchups take the spotlight during the Week 5 college football schedule. One of the headliners is Deion Sanders and the Colorado Buffaloes hosting Caleb Williams and the No. 8 USC Trojans at noon ET. The Buffaloes are 21.5-point underdogs in the Week 5 college football odds according to the SportsLine consensus. No. 2 Michigan is traveling to Nebraska and the Wolverines are favored by 18 points in that Big Ten battle. And in one of the more intriguing SEC showdowns of the week, No. 20 Ole Miss (+2.5) hosts No. 13 LSU.

Which of those Week 5 college football spreads have value, and how should you play other big matchups such as Georgia vs. Auburn (+14.5) (3:30 p.m. ET, CBS) or Kansas vs. Texas (-16.5)? Before locking in any Week 5 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest college football odds for Week 5 and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 5

One of the college football picks the model is recommending for Saturday: Georgia (-14.5) easily covers the spread at Auburn in a 3:30 p.m. ET SEC on CBS kickoff at Jordan-Hare Stadium. The Tigers have struggled mightily against the Bulldogs in recent years. In fact, Auburn is 0-6 in its last six games against Georgia. In addition, the Tigers are 0-6 against the spread in their last six meetings with their SEC rivals.

Georgia's defense remains a strength for the Bulldogs and the Bulldogs are giving up just 11.25 points per game this season, which ranks 10th in the nation. Meanwhile, Hugh Freeze's offense has been inconsistent in his first season in charge of the Tigers. Auburn has scored 14 points or less in two of its last three games and SportsLine's model expects they'll stay under that total on Saturday, helping the Bulldogs cover the spread in well over 60% of simulations. 

Another prediction: Michigan State (+10.5) nearly pulls off an outright upset at Iowa on Saturday at 7:30 p.m. ET. Both teams are coming off rough losses with Michigan State falling 31-9 to Maryland and Iowa getting blown out 31-0 to Penn State last week. Iowa had one of the worst offensive performances of the college football season, totaling just 76 yards and four first downs with 14:33 time of possession.

Michigan State's offense had five turnovers against Maryland last weekend after turning the ball over just three times in its 2-1 start. If the Spartans can eliminate those turnovers against Iowa, it could be tough for the Hawkeyes offense to go on long drives in an offense that is averaging 14.7 points per game in three games outside of a 41-10 victory over Western Michigan of the MAC. The model doesn't project Iowa's offense to be strong enough to justify being nearly a two-touchdown favorite and is predicting a one-score contest with Michigan State covering the spread in 70% of simulations. See which other teams the model likes here.

How to make college football picks for Week 5

The model has also made the call on who wins and covers in every other FBS matchup in Week 5, and it's calling for several underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned nearly $2,500 in profit since its inception, and find out.

College football odds for top Week 5 games 

See full Week 5 college football picks, odds, predictions here

Saturday, Sep. 30

Florida vs. Kentucky (-1, 44.5)

Clemson vs. Syracuse (+7, 53)

Penn State vs. Northwestern (+26.5, 47)

USC vs. Colorado (+21.5, 73)

Georgia vs. Auburn (+14.5, 45)

Michigan vs. Nebraska (+18, 40)

Kansas vs. Texas (-16, 61)

Missouri vs. Vanderbilt (+14, 54.5)

LSU vs. Ole Miss (+2.5, 67.5)

Oregon vs. Stanford (+20, 60)

Iowa State vs. Oklahoma (-19.5, 48.5)

Notre Dame vs. Duke (+5.5, 52.5)

South Carolina vs. Tennessee (-11.5, 60)

Alabama vs. Mississippi State (+14.5, 46)

Washington vs. Arizona (+18.5, 66)

Nevada vs. Fresno State (-24.5, 50.5)