Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | J. GoffJared Goff | T. BridgewaterTeddy Bridgewater | |
| Running Back | D. MontgomeryDavid Montgomery | J. GibbsJahmyr Gibbs | |
| Fullback | J. CabindaJason Cabinda | — | — |
| Wide Receiver | A. St. BrownAmon-Ra St. Brown | J. ReynoldsJosh Reynolds | |
| Tight End | S. LaPortaSam LaPorta | B. WrightBrock Wright | |
| Left Tackle | T. DeckerTaylor Decker | — | — |
| Left Guard | J. JacksonJonah Jackson | C. SorsdalColby Sorsdal | — |
| Center | F. RagnowFrank Ragnow | K. AwosikaKayode Awosika | — |
| Right Guard | H. VaitaiHalapoulivaati Vaitai | G. GlasgowGraham Glasgow | — |
| Right Tackle | P. SewellPenei Sewell | — | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | A. HutchinsonAidan Hutchinson | J. PaschalJosh Paschal | — |
| Right Defensive End | C. HarrisCharles Harris | L. OnwuzurikeLevi Onwuzurike | |
| Left Defensive Tackle | A. McNeillAlim McNeill | J. CominskyJohn Cominsky | — |
| Right Defensive Tackle | B. JonesBenito Jones | I. BuggsIsaiah Buggs | |
| Strongside Linebacker | D. BarnesDerrick Barnes | J. HoustonJames Houston | — |
| Middle Linebacker | A. AnzaloneAlex Anzalone | M. RodriguezMalcolm Rodriguez | |
| Weakside Linebacker | J. CampbellJack Campbell | A. PittmanAnthony Pittman | — |
| Right Cornerback | J. JacobsJerry Jacobs | E. MoseleyEmmanuel Moseley | |
| Left Cornerback | C. SuttonCameron Sutton | S. GilmoreSteven Gilmore | |
| Strong Safety | T. WalkerTracy Walker | I. MelifonwuIfeatu Melifonwu | — |
| Free Safety | K. JosephKerby Joseph | B. BranchBrian Branch |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | J. FoxJack Fox | — | — |
| Kicker | R. PattersonRiley Patterson | — | — |
| Long Snapper | S. DalyScott Daly | — | — |
| Holder | J. FoxJack Fox | — | — |
| Punt Returner | K. RaymondKalif Raymond | — | — |
| Kick Returner | Z. KnightZonovan Knight | K. RaymondKalif Raymond |