Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | B. YoungBryce Young | A. DaltonAndy Dalton | — |
| Running Back | C. HubbardChuba Hubbard | M. SandersMiles Sanders | |
| Wide Receiver | A. ThielenAdam Thielen | J. MingoJonathan Mingo | |
| Tight End | H. HurstHayden Hurst | T. TrembleTommy Tremble | |
| Left Tackle | I. EkwonuIkem Ekwonu | R. Lee IIIRicky Lee III | — |
| Left Guard | N. JensenNash Jensen | J. McCrayJustin McCray | — |
| Center | B. BozemanBradley Bozeman | — | — |
| Right Guard | C. MaysCade Mays | — | — |
| Right Tackle | T. MotonTaylor Moton | D. SharpeDavid Sharpe | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | D. WilliamsDeShawn Williams | L. RayLaBryan Ray | — |
| Nose Tackle | S. TuttleShy Tuttle | N. ThurmanNick Thurman | — |
| Right Defensive End | D. BrownDerrick Brown | H. AndersonHenry Anderson | — |
| Left Inside Linebacker | D. JonesDeion Jones | K. Grugier-HillKamu Grugier-Hill | |
| Right Inside Linebacker | F. LuvuFrankie Luvu | T. DavisTae Davis | |
| Strongside Linebacker | Y. Gross-MatosYetur Gross-Matos | A. BarnoAmare Barno | |
| Weakside Linebacker | B. BurnsBrian Burns | M. HaynesMarquis Haynes | |
| Right Cornerback | J. HornJaycee Horn | C. HendersonC.J. Henderson | |
| Left Cornerback | D. JacksonDonte Jackson | J. ChinnJeremy Chinn | |
| Strong Safety | V. BellVonn Bell | A. CookAlex Cook | |
| Free Safety | X. WoodsXavier Woods | S. FranklinSam Franklin |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | J. HekkerJohnny Hekker | — | — |
| Kicker | E. PineiroEddy Pineiro | — | — |
| Long Snapper | J. JansenJ.J. Jansen | — | — |
| Holder | J. HekkerJohnny Hekker | — | — |
| Punt Returner | R. BlackshearRaheem Blackshear | I. Smith-MarsetteIhmir Smith-Marsette | — |
| Kick Returner | R. BlackshearRaheem Blackshear | I. Smith-MarsetteIhmir Smith-Marsette |