Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | J. AllenJosh Allen | M. TrubiskyMitch Trubisky | |
| Running Back | J. CookJames Cook | R. DavisRay Davis | |
| Fullback | R. GilliamReggie Gilliam | — | — |
| Wide Receiver | K. ShakirKhalil Shakir | K. ColemanKeon Coleman | |
| Tight End | D. KnoxDawson Knox | D. KincaidDalton Kincaid | |
| Left Tackle | D. EdwardsDavid Edwards | T. GrableTylan Grable | |
| Center | C. McGovernConnor McGovern | S. Van Pran-GrangerSedrick Van Pran-Granger | — |
| Right Tackle | O. TorrenceO'Cyrus Torrence | R. Van DemarkRyan Van Demark |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | G. RousseauGreg Rousseau | J. SolomonJavon Solomon | — |
| Right Defensive End | J. BosaJoey Bosa | A. EpenesaA.J. Epenesa | — |
| Left Defensive Tackle | D. JonesDaQuan Jones | D. CarterDeWayne Carter | |
| Right Defensive Tackle | E. OliverEd Oliver | L. OgunjobiLarry Ogunjobi | — |
| Strongside Linebacker | D. WilliamsDorian Williams | B. SpectorBaylon Spector | |
| Middle Linebacker | T. BernardTerrel Bernard | — | — |
| Weakside Linebacker | M. MilanoMatt Milano | E. UlofoshioEdefuan Ulofoshio | — |
| Right Cornerback | D. JacksonDane Jackson | — | |
| Left Cornerback | C. BenfordChristian Benford | B. CodringtonBrandon Codrington | |
| Slot Cornerback | T. JohnsonTaron Johnson | C. LewisCam Lewis | — |
| Strong Safety | T. RappTaylor Rapp | C. BishopCole Bishop | — |
| Free Safety | D. HamlinDamar Hamlin | D. ForrestDarrick Forrest | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | J. CamardaJake Camarda | B. RobbinsBrad Robbins | — |
| Kicker | T. BassTyler Bass | — | — |
| Long Snapper | R. FergusonReid Ferguson | — | — |
| Holder | J. CamardaJake Camarda | — | — |
| Punt Returner | B. CodringtonBrandon Codrington | — | — |
| Kick Returner | B. CodringtonBrandon Codrington | L. Shenault Jr.Laviska Shenault Jr. |