The 2022 World Series could come to an end on Saturday as Game 6 between the Houston Astros and Philadelphia Phillies unfolds at 8:03 p.m. ET in Houston. The Astros have a 3-2 lead in the Fall Classic 2022, but it's been a back-and-forth series that has included everything from offensive outbursts to a no-hitter. That leaves some tough calls for MLB DFS players looking to assemble their lineups on daily Fantasy sites like FanDuel and DraftKings.

Bryce Harper, Rhys Hoskins, Yuli Gurriel, Jeremy Pena and Alex Bregman are some of the highest-priced hitters in this single-game MLB DFS player pool. The starting pitchers, meanwhile, are Zack Wheeler for the Phillies and Framber Valdez for the Astros. Who should you build your MLB DFS lineups around? Before making any MLB DFS picks for Game 6 of the 2022 World Series, be sure to check out the MLB DFS advice, strategy and projections from SportsLine daily Fantasy expert Mike McClure.

McClure is a daily Fantasy pro who has won over $2 million in his career. And when it comes to daily Fantasy baseball, McClure is at his best. Recognized in the book "Fantasy Football (and Baseball) for Smart People: How to Turn Your Hobby into a Fortune" as a top MLB DFS player, McClure's proprietary projection model simulates each game 10,000 times, taking factors such as matchups and recent results into account. This allows him to find the best values on every site.

On Thursday, McClure highlighted Pena on his FanDuel MVP list. The result: Pena went 3-for-4 with a home run and two RBI to produce 28.2 points on FanDuel. Anybody that included him in their lineups was well on the way to a profitable day.

Now, as the 2022 World Series continues, McClure has locked in his top MLB daily Fantasy picks for Game 6 of the 2022 World Series. Head to SportsLine now to see them.

McClure's top MLB DFS picks for World Series Game 6

One of McClure's top MLB DFS picks for Game 6 of the 2022 World Series is Astros outfielder Chas McCormick. Not the household name many of the other hitters in this lineup are, McCormick has been steady for the past two years in Houston, hitting 14 home runs in both 2021 and 2022 with an average that has hovered around .250. He has carried that consistency into the 2022 MLB playoffs, hitting .250 with an OPS of .774, both the fourth-best mark on the team for Houston.

He's seen Wheeler just twice in his career, but both at-bats were productive as he recorded one hit and one walk. With at least one hit in eight of 11 postseason games this season, McCormick has a great chance to return value on his affordable price in Game 6 on Saturday. 

Another part of McClure's optimal MLB DFS strategy for Saturday includes rostering Phillies outfielder Kyle Schwarber. The former Cubs stalwart has turned into a slugging mercenary of sorts, playing for the Red Sox, Nationals and now the Phillies in the last two seasons and hitting for incredible power at every stop along the way.

Schwarber combined to hit 32 home runs while posting a .928 OPS in 113 games for the Red Sox and Nationals a year ago and he led the National League with 46 home runs for the Phillies in 2022. He homered on Thursday night to give him two home runs over his last three World Series games and he's now hit five home runs during the 2022 MLB playoffs.

How to set your MLB DFS lineups for Saturday, Nov. 5, 2022 

McClure is also targeting an undervalued player who is set to explode for huge numbers in Game 6 of World Series 2022. The stars are aligning for him to return tournament-winning value and he comes at a price that won't break the bank. You can only see who it is here.

So what are the top MLB DFS picks for Game 6 of the 2022 MLB World Series? And which player is a must-roster? Visit SportsLine now to see DFS millionaire Mike McClure's complete player pool and picks for FanDuel and DraftKings, and cash in big on MLB DFS.