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From game-time decisions to injuries so significant they affect the value of every single position, let's break down the Fantasy and DFS impact of injuries for every Week 7 matchup. Know when to pivot and how your fantasy roster will be affected.

Below, you'll find a game-by-game look at the injuries you need to know that will have the biggest impact for Fantasy leagues, as well as the implications for DFS players. This week's list of notable names includes quarterbacks Jimmy Garoppolo, Daniel Jones and Deshaun Watson; running backs David Montgomery, Kyren Williams, Saquon Barkley and Khalil Herbert; receivers DK Metcalf, Tyler Lockett and Diontae Johnson; tight ends Dalton Kincaid and Pat Freiermuth; and many others, including key offensive line and defensive injuries to know.

You can also see how this week's injuries affect the Fantasy projections from the SportsLine Projection Model. All you have to do is head over to SportsLine's companion post to this piece that tracks all the projections you need to know related to this week's injury report.

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 1:00 pm ET •
BAL -3, O/U 43

Lions

Ravens

  • OLB Odafe Oweh (ankle) - Cleared
  • CB Kevon Seymour (ankle) - Out
  • FS Marcus Williams (hamstring) - Out

David Montgomery is out, Craig Reynolds is questionable, and Jahmyr Gibbs has been cleared and could see a significant workload in Week 7. Gibbs served as the lead back earlier in the season when Montgomery missed a game and saw a strong workload on the ground in terms of carries. However, it wasn't productive from a Fantasy perspective. Despite the prior underwhelming performance, Gibbs is a strong RB2 this week given his explosive upside and lack of running backs due to injuries and bye weeks. Baltimore's defense has been stout against the pass so attacking on the ground could be part of the Lions' strategic approach this week, despite the absence of Ravens safety Marcus Williams.

Sam LaPorta is cleared and remains a top-10 option this week..

DFS impact

Unfortunately, there's no priced discount on Gibbs. But, his $6,300 DraftKings salary, combined with general skepticism, could make Gibbs a strong low-owned contrarian play.

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 1:00 pm ET •
CHI +2.5, O/U 37.5

Notable injuries

Raiders

Bears

  • QB Justin Fields (thumb) - Out
  • RB Roschon Johnson (concussion) - Out
  • RB Travis Homer (hamstring) - Cleared
  • OG Nate Davis (ankle) - Out
  • OT Darnell Wright (shoulder) - Questionable
  • SAF Eddie Jackson (foot) - Out
  • SAF Jaquan Brisker (groin) - Questionable

Justin Fields is out for Week 7 and Tyson Bagent will get the start. Bagent lowers the upside for Bears pass catchers in general but D.J. Moore is still a flex option. However, players in shallow leagues can pivot to more trustworthy options this week.

Roschon Johnson has been ruled out for the second week in a row with a concussion, so D'Onta Foreman remains the lead back for the Bears. Despite the underwhelming performance from Fantasy perspective in Week 6, Foreman is a top-24 back in Week 7 given the excellent matchup against the Vegas defense that has allow strong performances from even the most struggling backs, including a Week 6 performance from A.J. Dillon that was his best of the season.

Jimmy Garoppolo is out for Week 7, and Brian Hoyer will reportedly start in his place. Hoyer had six completions on just 10 attempts after Garoppolo suffered his injury last week. It's tough to know Hoyer's exact preferences but he'll likely lean on Davante Adams, though the offense should rely heavily on Josh Jacobs.

DFS impact

It's best to pivot away from pass catchers as a whole in this matchup. The running backs of the most viable options. Foreman is an interesting option in tournaments at just $4,800 on DraftKings.  

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 1:00 pm ET •
IND +3, O/U 40.5

Notable injuries

Browns

  • QB Deshaun Watson (shoulder) - Questionable
  • RB Kareem Hunt (thigh) - Questionable
  • TE Harrison Bryant (hip) - Questionable
  • OG Joel Bitonio (knee) - Cleared
  • LB Anthony Walker (concussion) - Cleared
  • LB Sione Takitaki (hamstring) - Out
  • CB Greg Newsome II (hamstring) - Questionable

Colts

  • WR Alec Pierce (shoulder) - Questionable
  • TE Jelani Woods (hamstring) - TBD
  • TE Kyle Granson (concussion) - Out
  • OT Braden Smith (foot) - Out

The Colts continue without Anthony Richardson, who will miss the remainder of the season. Cleveland's injuries are offensively focused, making the entire Colts offense risky options in Week 7. It's possible that Josh Downs sees an increased workload if Pierce is unable to play. Pierce hasn't contributed from a Fantasy perspective but his snap count has been consistently above Downs' snap count.

The big question in this matchup is around the health of Deshaun Watson. Fantasy managers must monitor Watson's status throughout the weekend but he seems to be trending towards playing. His return would be significant for the Browns offense as a whole. The Browns found some stability with P.J. Walker last week and relied on their ground game but Watson is needed to unlock the offense's upside. Cooper should start in most leagues regardless of Watson's status, but his return would open the door for Elijah Moore as a deep flex option.

Kareem Hunt is question coming off a big Week 6 performance. Jerome Ford still operated as the lead back but if Hunt is out, Ford is a strong play in all formats.

DFS impact

The Browns are salary-friendly as a whole with Watson at just $5,700 in a good matchup. Watson is still not the ideal start for cash or tournament play but Jerome Ford at $5,100 is the most appealing value play in this matchup if Hunt is out or limited. 

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 1:00 pm ET •
NE +8.5, O/U 40

Notable injuries

 Bills

  • QB Josh Allen (shoulder) - Cleared
  • RB Damien Harris (concussion) - IR
  • TE Dalton Kincaid (concussion) - Cleared
  • DT Ed Oliver (toe) - Out

Patriots

The Bills have placed Damien Harris on IR, and while he didn't make a significant impact on the field, his snaps will likely go to Latavius Murray, who is a viable flex option this week in a matchup with a New England team that continues to deal with significant injuries on offense and defense. The Bills' entire offense is a strong play, even players that have questionable upside like James Cook and Dalton Kincaid -- who was cleared from the injury report. If the Bills jump out to an aggressive lead, Murray could have a stronger workload in the second half of the game.

Kendrick Bourne benefited from increased opportunities in Week 6 with injuries to New England pass catchers. Bourne remains a streaming option in deep leagues.

DFS impact

Given the likelihood of New England trailing, Bourne is a potential value play at just $4,400 on DraftKings. The Bills are strong but pricy options against this depleted New England defense. Buffalo's defense remains a very appealing option in this matchup.

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 1:00 pm ET •
NYG +2.5, O/U 37.5

Notable injuries

Commanders

  • DE Jonathan Allen (knee) - Cleared
  • CB Kendall Fuller (knee) - Cleared
  • CB Christian Holmes (hamstring) - Cleared

Giants

Saquon Barkley had limited practices earlier in the week, but is cleared to play heading into the weekend. Barkley had a strong performance with a hefty workload in Week 6 coming off a multiweek absence and will likely see a significant workload again with the Giants relying on the run game due to Daniel Jones' injury situation.

Fantasy managers must monitor status for Jones throughout the weekend. He's a risky play in most formats, outside of Superflex leagues. The matchup with Washington is ideal but expect Jones to defer to Barkley if Jones is active. The Giants has multiple injuries across the offensive line but Washington is an excellent matchup for opposing running backs.

DFS impact

Barkley has top-five upside this week and is a strong play in both cash and tournaments. Again, given the issues with Daniel Jones, Barkley is a strong candidate to see over 20 touches and should be productive, despite line issues .

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 1:00 pm ET •
TB -2.5, O/U 37

Notable injuries

Falcons

  • None

Bucccaneers

  • DT Vita Vea (foot) - Questionable
  • LB Anthony Nelson (concussion) - Questionable

The Bucs injury list is short but impactful. Vita Vea is questionable for Tampa Bay but he did return to practice on a limited capacity on Friday. The Bucs have been one of the toughest matchups for opposing running backs and if Vea is unable to suit up, his absence could open up space for Bijan Robinson. Vea also lead the team in sacks.

DFS impact

It's difficult to pull trustworthy, high-upside players from this matchup but Robinson could be a contrarian play if the Bucs defense is without Vea.  

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 4:05 pm ET •
SEA -7.5, O/U 44.5

Notable injuries

Cardinals

  • WR Zach Pascal (neck) - Questionable
  • OT Elijah Wilkinson (neck) - Out
  • DT Kevin Strong (calf) - Questionable
  • CB Kei'Trel Clark (hamstring) - Questionable
  • SS Budda Baker (hamstring) - TBD
  • SAF Jalen Thompson (hamstring) - Out

Seahawks

  • RB Zach Charbonnet (hamstring) - Questionable
  • WR DK Metcalf (ribs, hip) - Questionable
  • WR Tyler Lockett (hamstring) - Cleared
  • C Evan Brown (hip) - Questionable
  • OT Charles Cross (ankle) - Cleared
  • OT Jake Curhan (ankle) - Questionable

Budda Baker would be a welcome return for Arizona. He logged multiple limited practices this week but his status remains in question. The Cardinals have struggled on defense and injuries only exacerbate the issue.

The most important injury to monitor in this matchup the status of DK Metcalf. If Metcalf misses Week 7, Jaxon Smith-Njigba is a flex option in all formats. Smith-Njigba has maintain a steady presence in the Seahawks receiving corps but opportunities are limited behind Metcalf and Tyler Lockett. He could thrive in this matchup.

Although Zach Charbonnet has yet to make a significant contribution from a Fantasy perspective, his absence is important to note because Kenneth Walker has thrived off volume this season and Charbonnet's potential absence could increase that volume.

DFS impact

If Metcalf is absent, both Lockett and Smith-Njigba are strong plays in DFS. Lockett would have WR1 upside at $6K and Smith-Njigba is just $3,900.

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 4:05 pm ET •
LAR -3, O/U 44

Notable injuries

Steelers

  • WR Diontae Johnson (hamstring) - Cleared
  • TE Pat Freiermuth (hamstring) - Out
  • OLB T.J. Watt (heel) - Cleared

Rams

Pat Freiermuth was set to return this week after practicing in full on Wednesday but suffered a setback and will miss Week 7. While Darnell Washington saw increased time in Freiermuth's absence, his increased snap count had no value for Fantasy purposes. Diontae Johnson will return from IR this week after logging multiple full practices, and Fantasy managers should feel comfortable starting him in Week 7. Cooper Kupp's return from IR post-hamstring injury is a good comp for Fantasy managers worried about any limitations. Johnson should see a solid workload and targets should be primarily focused on Johnson and George Pickens

Kyren Williams is out for Week 7 and Ronnie Rivers was placed on IR, leaving the Rams backfield to Zach Evans, Royce Freeman, Myles Gaskin and Darrell Henderson. It's difficult to trust this backfield but with injuries and bye weeks forcing unreliable backs up our rankings, Zach Evans is a viable start this week. The backfield may operate as a committee but Evans should have priority. Evans' first carries came in Week 6, so there is very little reference point around his potential upside within this offense. But the Steelers are top 10 in points allowed to opposing running backs so any back getting double-digit carries for the Rams is Fantasy relevant.

DFS impact

Johnson is just $5,000 in this matchup on DraftKings. The Rams have been a difficult matchup for opposing receivers but Johnson could be a contrarian play in tournaments. George Pickens is still a good value play despite Johnson's return at just $5,500. Evans is just $4K on DraftKings but unless we get confirmation around his potential workload, he's a risky option even at cost. Given the potential value, if the Rams give indication Evans will lead the backfield, he's a value play in tournaments.

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 4:25 pm ET •
DEN +1, O/U 45

Notable injuries

Packers

  • RB Aaron Jones (hamstring) - Questionable
  • OT Yosh Nijman (knee) - Questionable
  • OG Elgton Jenkins (knee) - Questionable
  • DT Devonte Wyatt (knee) - Questionable
  • OLB De'Vondre Campbell (ankle) - Doubtful
  • LB Quay Walker (knee) - Questionable
  • CB Jaire Alexander (back) - Questionable
  • CB Eric Stokes (foot) - Questionable
  • SAF Darnell Savage (calf) - Questionable

Broncos

  • TE Greg Dulcich (hamstring) - Out
  • SAF Justin Simmons (knee) - Cleared

Lack of clarity around Aaron Jones makes him a risky play in Week 7, but with an excellent matchup against a porous Denver defense, he's still a top-24 option if active. Christian Watson was removed from the injury report this week and should see a full workload.

Greg Dulcich returned to action for Denver last week but suffered a setback and is out for Week 7.

DFS impact

Although the matchup is ideal, avoid Packers running backs unless we have clarity around status and workload for Jones. Lean into the Packers receivers with Christian Watson at $5,600, Romeo Doubs at $4,900 and Luke Musgrave at $3,300.

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 4:25 pm ET •
KC -5.5, O/U 48

Notable injuries

Chargers

  • WR Jalen Guyton (knee) - Cleared
  • DT Sebastian Joseph-Day (knee) - TBD
  • LB Joey Bosa (toe) - Cleared
  • SS Alohi Gilman (heel) - Out
  • FS Derwin James (ankle) - Questionable

Chiefs

  • WR Justin Watson (elbow) - Out
  • CB Jaylen Watson (thigh) - Questionable

Joey Bosa logged a full practice on Friday and is cleared to play. Unfortunately, the Chargers defense will likely continue to struggle. Derwin James seems to be trending in the wrong direction and Alohi Gilman is out. The Chiefs have strong upside in this matchup and a player like Rashee Rice becomes a potential flex option.

Although unrelated to injury, Fantasy managers should note Mecole Hardman returned to the Chiefs via trade. It's unclear if he'll play this week.

DFS impact

Injuries have little impact in this matchup. Both sides have strong plays for DFS as a whole.

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Sun, Oct 22 at 8:20 pm ET •
PHI -2.5, O/U 51.5

Notable injuries

Dolphins

  • RB Jeff Wilson (ribs) - Cleared
  • FB Alec Ingold (foot) - Questionable
  • Connor Williams (groin) - Questionable
  • CB Jalen Ramsey (knee) - Out
  • CB Nik Needham (Achilles) - Questionable
  • CB Kader Kohou (neck) - Cleared
  • CB Xavien Howard (groin) - Questionable

Eagles

  • WR DeVonta Smith (hamstring) - Cleared
  • TE Dallas Goedert (groin) - Cleared
  • OT Lane Johnson (ankle) - Cleared
  • DT Jalen Carter (ankle) - Cleared
  • CB Bradley Roby (shoulder) - Out
  • FS Reed Blankenship (ribs) - Out

Jeff Wilson is set to return to action this week but it's unlikely that his return makes a dent in the workload for Raheem Mostert. Despite the difficult matchup, Mostert is still a top-12 running back this week. The Dolphins continue to deal with injuries to their secondary and Jalen Ramsey will not return this week. DeVonta Smith and Dallas Goedert were cleared and are strong options against the Miami defense.

DFS impact

The matchup features the highest over/under of the week and injuries have no significant impact on the showdown. Both sides feature very strong options.

Start 'em
10.0-7.00
6.99 - 5.01
5.00 - 0
Sit 'em
Mon, Oct 23 at 8:15 pm ET •
MIN +6.5, O/U 44

Notable injuries

49ers

  • RB Christian McCaffrey (oblique) - TBD
  • WR Deebo Samuel (shoulder) - TBD
  • OT Trent Williams (ankle) - TBD
  • OG Aaron Banks (ankle) - TBD
  • LB Dre Greenlaw (hamstring) - TBD
  • CB Isaiah Oliver (knee) - TBD

Vikings

  • WR Jalen Nailor (hamstring) - TBD
  • OG Ezra Cleveland (foot) - TBD
  • CB Akayleb Evans (oblique) - TBD

Perhaps the most critical injury of the week, Fantasy managers must monitor the status for Christian McCaffrey throughout the weekend. McCaffrey's injury is not as serious as the initial report but it's unclear if he'll be able to play. Fantasy managers should monitor his status and prepare to pivot to another option on Sunday if the news is still unclear.

If McCaffrey is out, Elijah Mitchell and Jordan Mason are potential flex options this week. We have no clear direction on who would be the preferred back but Mitchell's extensive history and production within the offense likely puts him in line for the start if McCaffrey is out.

Deebo Samuel's status remains in question. If Samuel is out, upside is huge for both Brandon Aiyuk and George Kittle.

DFS impact

Focus on the 49ers in this matchup. Even with the potential injuries to McCaffrey and Samuel, the 49ers offense should bounce back after a tough showing against the Browns last week. The Vikings offense is difficult to trust in this matchup outside of T.J. Hockenson.