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The No. 11 Penn State Nittany Lions (9-2) will try to extend their three-game winning streak and earn a spot in a New Years Six bowl game when they face the Michigan State Spartans (5-6) on Saturday afternoon. Penn State has won all three of those games in blowout fashion, including a 55-10 win at Rutgers last week. Michigan State had its two-game winning streak snapped in a 39-31 double-overtime loss to Indiana. The Spartans need a win to become bowl eligible. 

Kickoff is set for 4 p.m. ET. The Nittany Lions are favored by 18.5 points in the latest Penn State vs. Michigan State odds from Caesars Sportsbook, while the over/under is set at 52.5. Before entering any Michigan State vs. Penn State picks, you'll want to see the college football predictions and betting advice from the proven computer simulation model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Penn State vs. Michigan State and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds for Penn State vs. Michigan State:

  • Penn State vs. Michigan State spread: Penn State -18.5
  • Penn State vs. Michigan State over/under: 52 points
  • Penn State vs. Michigan State money line: Penn State -1100, Michigan State 700
  • Penn State vs. Michigan State picks: See picks here
Featured Game | Penn State Nittany Lions vs. Michigan State Spartans

Why Penn State can cover

Outside of losses to Michigan and Ohio State, Penn State has been outstanding this season. The Nittany Lions have won their other nine games, including each of their last three. They have won all three of those games by at least 30 points, blowing out Rutgers in a 55-10 final last week. 

Head coach James Franklin recorded win No. 100 in the win over the Scarlet Knights, as quarterback Sean Clifford threw for a touchdown and ran for another. The Nittany Lions also scored on a kickoff return and two fumble returns, giving them a ton of momentum heading into Senior Day. They have covered the spread in five straight games, while Michigan State has only covered twice in its last nine games. 

Why Michigan State can cover

Penn State has been dominant of late, but it is having to deal with the distractions of Senior Day festivities on Saturday. The Nittany Lions are going to be without star wide receiver Parker Washington, who is out for the season with an undisclosed injury. Washington had 46 receptions for 611 yards before going down, so his absence is a key factor in this matchup. 

Michigan State notched a road win at then-No. 16 Illinois in early November as a 16-point underdog, so it is comfortable playing in this role. The Spartans have won and covered the spread in six of the last nine meetings between these teams. Junior quarterback Payton Thorne has thrown for 2,450 yards and 18 touchdowns, while running back Jalen Berger has rushed for 669 yards and six touchdowns. 

How to make Michigan State vs. Penn State picks

The model has simulated Penn State vs. Michigan State 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins Michigan State vs. Penn State? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Penn State vs. Michigan State spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.