The No. 2 Ohio State Buckeyes will look to continue their recent mastery of the third-ranked Michigan Wolverines with the Big Ten Conference East Division title on the line in The Game on Saturday. The winner will earn a trip to Indianapolis for the Big Ten Championship Game, and an inside track at making the College Football Playoff. The Buckeyes (11-0, 8-0), who have won or shared the past 10 Big Ten East titles, have beaten Michigan in 17 of the past 20 meetings. The Wolverines (11-0, 8-0), who beat Ohio State 42-27 last year, have won 43 Big Ten Championships through the years. Michigan running back Blake Corum (knee) left last week's game, but multiple reports indicate he'll play in this one. 

Kickoff from Ohio Stadium in Columbus, Ohio, is set for noon ET. Ohio State averages 492.7 yards per game in 2022, while Michigan averages 452.6. The Buckeyes are favored by 8 points in the latest Michigan vs. Ohio State odds from Caesars Sportsbook, while the over-under for total points scored is 56. Before making any Ohio State vs. Michigan picks, you need to see the college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ohio State vs. Michigan and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Now, here are several college football odds and betting lines for Michigan vs. Ohio State:

  • Michigan vs. Ohio State spread: Ohio State -8
  • Michigan vs. Ohio State over-under: 56 points
  • Michigan vs. Ohio State money line: Michigan +250, Ohio State -320
  • MICH: The Wolverines are 5-1 against the spread in their last six road games
  • OSU: The Buckeyes are 4-0-1 ATS in their last five home games
  • Michigan vs. Ohio State picks: See picks at SportsLine
Featured Game | Ohio State Buckeyes vs. Michigan Wolverines

Why Ohio State can cover

The Buckeyes have a three-pronged rushing attack, led by junior running back Miyan Williams, who leads the team with 117 carries for 783 yards and 13 touchdowns. He is fifth nationally in yards per carry at 6.7 among backs with 60 or more attempts. Williams missed last week's game with a lower leg injury but is expected back to face the Wolverines. His best game was a 21-carry, 189-yard and five-touchdown performance against Rutgers on Oct. 1.

Sophomore Treveyon Henderson and freshman Dallan Hayden also solidify the running back position. Henderson has carried 107 times for 571 yards (5.3 average) and six touchdowns, including two against Penn State and two against Arkansas State. He also has a pair of 100-plus rushing performances, including a 21-carry, 121-yard effort against Wisconsin. Hayden has 100 carries for 503 yards and five scores, including a 27-carry, 146-yard and three-touchdown game last week at Maryland.

Why Michigan can cover

Senior wide receiver Ronnie Bell is the Wolverines' top pass catcher. He leads the team with 48 receptions for 641 yards (13.4 average) and two touchdowns. Bell's best game this year was an 11-catch, 121-yard performance at Indiana on Oct. 8. The returning captain from last season and two-time Biletnikoff Award candidate has played in 44 career games, including 28 starts. He became the 25th player in school history to have 1,500 receiving yards, and has 131 receptions for 2,021 yards and seven touchdowns.

Also leading the receiving corps is senior receiver Cornelius Johnson. For the season, he has 25 receptions for 300 yards (12.0 average) and four touchdowns. His best game so far this year was a four-catch, 58-yard and two-touchdown performance at Indiana on Oct. 8. The two-time Academic All-Big Ten player has played in 43 career games with 28 starts. He has 84 career receptions for 1,235 yards and 11 TDs.

How to make Michigan vs. Ohio State picks

SportsLine's model is leaning Over on the total, projecting a combined 65 points. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's CFB picks at SportsLine.

So who wins Ohio State vs. Michigan? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.