The Lions (2-0) were coming off a 21-20 victory over Houston Baptist in their first game as a Division I program.
Payton Rose made seven catches for 180 yards and a touchdown and Kobe Smith added 111 yards receiving and two scores for Lindenwood. Andrew Martin and Justin Williams each had a rushing touchdown.
Brister and Smith connected on a 78-yard touchdown pass to build a 21-3 lead.
Shea Spencer passed for 161 yards for Keiser.
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