Six College Football Playoff fields have featured at least one of Ohio State or Notre Dame, so there's a lot on the line when those powerhouses meet Saturday at 7:30 p.m. ET in the marquee non-conference matchup on the Week 4 college football schedule. The Week 4 college football odds via SportsLine consensus list the visiting No. 6 Buckeyes at -3 against the No. 9 Fighting Irish.

Other Week 4 college football lines of note include No. 13 Alabama (-7) against No. 15 Ole Miss (3:30 p.m. ET, CBS), No. 4 Florida State (-2) against Clemson, No. 7 Penn State (-14.5) against No. 24 Iowa (7:30 p.m. ET, CBS) and No. 10 Oregon (-21) against Deion Sanders and No. 19 Colorado. Before locking in any Week 4 college football picks on those games or others, be sure to see the top Week 4 college football expert picks, predictions and best bets from Barrett Sallee.

Sallee is a true insider -- a CBS Sports analyst, SiriusXM host, Heisman voter and consistently one of the top CBS Sports experts picking games against the spread. He debuted with SportsLine in 2017 and has delivered his three best college football picks to members each week. He swept his Week 3 best bets for SportsLine members, hitting Over 48.5 in FSU-Boston College, Under 59 in Tennessee vs. Florida and Washington -16 vs. Michigan State, all with room to spare.

Now, he has turned his attention to the Week 4 college football odds and is sharing his top three best bets over at SportsLine. If you parlay them together, you could be looking at a return of around 6-1. Get his top college football picks at SportsLine.

Top Week 4 college football expert predictions

One of Sallee's top Week 4 college football picks: He's backing No. 8 Washington (-21.5) to cover the three-score spread against California in a 10:30 p.m. ET Pac-12 kickoff at Husky Stadium.

Offense is the first thing that comes to mind when thinking about the Huskies. They've piled up eye-popping pass numbers as Heisman contender Michael Penix Jr. has cleared 400 yards through the air in all three games. He was 27 of 35 for 473 yards, four touchdowns and no interceptions in the 41-7 win over Michigan State in Week 3.

Sallee is impressed with what he's seen from that side of the ball, but he also believes Washington's defense, which is giving up just 12 points per game, is what makes this team special. "Is Cal going to be able to keep up in a track meet? Nope. Not against this defense and especially not at Husky Stadium," Sallee told SportsLine. See what other picks Sallee likes at SportsLine

How to make Week 4 college football picks 

Sallee has also found two other college football picks he loves, including saying one underdog will run away late in a game where "the wrong team is favored." You can only see his picks at SportsLine.

What are the best bets for Week 4 of college football, and which underdog will run away with an outright victory? Visit SportsLine now to see Barrett Sallee's college football best bets, all from one of the top analysts in the nation who swept his best bets last week, and find out.