South Alabama (6-2, 3-1 Sun Belt Conference) grabbed a 14-0 first-quarter lead on Webb's 3-yard touchdown run and Carter Bradley's 49-yard scoring strike to Jalen Wayne.
Webb had 1-yard scoring runs in the third and fourth quarters, finishing with 28 carries for the Lions. Bradley was 17-of-24 passing for 179 yards.
James Blackman completed 22 of 39 passes for 179 yards for the Red Wolves (2-7, 1-5), whose only score was a 32-yard first-quarter field goal by Dominic Zvada.
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