No. 8 USC will go on the road for the second week in a row when it travels to Colorado on Saturday. The Trojans played their first road game of the season last week, improving to 4-0 with a 42-28 win at Arizona State. Colorado opened the year with three straight wins, but came up well short in a 42-6 loss at then-No. 10 Oregon last week. The Buffaloes will be without two-way star Travis Hunter (lacerated liver) again on Saturday. 

Kickoff is scheduled for noon ET. The Trojans are 22.5-point favorites in the latest USC vs. Colorado odds, while the over/under for total points scored is 73. Before making any Colorado vs. USC picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed the model has seen huge returns.

Now, the model has set its sights on USC vs. Colorado and just revealed its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and trends for Colorado vs. USC:

  • USC vs. Colorado spread: Trojans -22.5
  • USC vs. Colorado over/under: 73 points
  • USC vs. Colorado money line: Trojans -1590, Buffaloes +873
  • USC: Caleb Williams leads the country in passing efficiency (223.1)
  • COL: Shedeur Sanders ranks second in the FBS in passing yards per game (352.5)
  • USC vs. Colorado: See picks at SportsLine 
  • USC vs. Colorado live stream: fubo (try for free)

Why USC can cover

Caleb Williams & Co. have a plus matchup going up against the Colorado pass defense. Led by Williams, the Trojans rank third in the country in passing offense (377.2 yards per game). They'll face a Buffaloes defense that allows 269.2 passing yards per game, which ranks 111th in the country. Last week Colorado was torched for 217 passing yards and three touchdowns in just the first half by Oregon.

In addition, the Buffaloes have had difficulty protecting the quarterback this season. With an offensive line featuring multiple transfers and a true freshman, Colorado gives up 5.75 sacks per game this season. That is the second most among all 130 FBS programs, behind only Old Dominion (6.50). Colorado two-way star Travis Hunter will also miss this game as he continues to recover from a lacerated liver. See which team to pick here.

Why Colorado can cover

Colorado's performance against Oregon was disastrous, but the Buffaloes covered the spread in outright wins over then-No. 17 TCU and Nebraska during the first two weeks of the season. While USC's offense has been elite, the Trojans have been mediocre on the defensive side of the ball. They allowed 28 points to both San Jose State and Arizona State, failing to cover the spread in either of those games.

The Buffaloes have an offense that can take advantage, scoring more than 35 points in each of their first three outings. Junior quarterback Shedeur Sanders has racked up 1,410 passing yards, 11 touchdowns and one interception, while running back Dylan Edwards is averaging 5.6 yards per carry. USC has not been meeting market expectations since the end of last season, covering the spread just two times in its last six games. See which team to pick here.

How to make USC vs. Colorado picks

SportsLine's model is leaning Under the point total. The model also says one side of the spread hits in well over 50% of simulations. You can see the model's picks at SportsLine

So who wins Colorado vs. USC, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of almost $2,500 on its top-rated college football spread picks, and find out.