The Buffalo Bulls will look to become bowl eligible for the seventh time in program history and fifth time in the last six seasons when they take on the Central Michigan Chippewas in MACtion on Wednesday night. The Bulls (5-4, 4-1), who are 3-3 on the road, are coming off a 45-24 loss at Ohio. Buffalo has won five of its last six games. The Chippewas (3-6, 2-3), who are 1-3 on their home field, have won two of three, including a 35-22 win at Northern Illinois last week.

Kickoff from Kelly/Shorts Stadium in Mount Pleasant, Mich., is set for 7 p.m. ET. The Chippewas are listed as 2.5-point favorites in the latest Buffalo vs. Central Michigan odds from Caesars Sportsbook, while the over/under for total points scored is 53. Before making any Central Michigan vs. Buffalo picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Buffalo vs. Central Michigan and just locked in its picks and MACtion predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Central Michigan vs. Buffalo:

  • Buffalo vs. Central Michigan spread: CMU -2.5
  • Buffalo vs. Central Michigan over-under: 53 points 
  • Buffalo vs. Central Michigan money line: Buffalo +115, Central Michigan -135
  • BUF: The Bulls are 5-1-1 against the spread in their last seven games overall 
  • CMU: The Chippewas are 14-1-1 ATS in their last 16 Wednesday games 
  • Buffalo vs. Central Michigan picks: See picks here
Featured Game | Central Michigan Chippewas vs. Buffalo Bulls

Why Buffalo can cover

Buffalo's defense has flexed its muscles in recent weeks as the Bulls have scored a defensive touchdown in three of the last four games. Linebacker James Patterson had a 97-yard fumble recovery for a touchdown at Bowling Green, safety Jahmin Muse had a 72-yard fumble return against Toledo and safety Keyshawn Cobb had a 26-yard interception return for touchdown at Ohio. Junior linebacker Shaun Dolac has been dominant in recent weeks, registering double-digit tackles in five of the last six games. He leads the nation in solo tackles with 68 and ranks second in the MAC in total tackles with 95.

The Bulls have had a number of different players make big plays on offense this season. Six different Buffalo players have registered a play of 40 yards or longer. Wide receiver Jamari Gassett leads the way with three explosive plays, including 65, 47 and 44-yard receptions. Wide receiver Justin Marshall has a 69- and 49-yard TD reception, while fellow wideout Quian Williams has two 59-yard touchdown receptions. 

Why Central Michigan can cover 

Despite that, the Bulls are not a lock to cover the Buffalo vs. Central Michigan spread. That's because the Chippewas are hard to beat in November, and are 11-1 in the month during coach Jim McElwain's four-year tenure. The only loss during that time was in 2020. Sophomore Daniel Richardson and redshirt freshman Jase Bauer have split time at quarterback, with the two combining for nearly 2,200 yards passing. Richardson has thrown for 15 touchdowns, but has been picked off five times, while Bauer has one TD pass and one interception, while rushing for four touchdowns.

Leading Central Michigan's rushing attack is sophomore running back Lew Nichols III. Nichols has carried 160 times for 561 yards (3.5 average) and six touchdowns. He also has 20 receptions for 128 yards (6.4 average). Nichols has had a solid career at CMU, earning the Mid-American Conference Freshman of the Year Award in 2021 and the MAC Offensive Player of the Year Award in 2022.

How to make Buffalo vs. Central Michigan picks

SportsLine's model is leaning Over on the total, projecting the teams to combine for 60 points. It has also generated an against-the-spread pick that hits in well over 50% of simulations. You can only get the model's pick at SportsLine

So who wins Buffalo vs. Central Michigan? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Buffalo vs. Central Michigan spread to jump on, all from the advanced model that finished the past six-plus years up nearly $3,000 on its FBS college football picks, and find out.