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The Penn State Nittany Lions (4-0) and the Virginia Tech Hokies (4-0) match up in the semifinals of the 2022 Charleston Classic on Friday. Both teams have won four straight games and have eyes on making it five. In the opening round, Penn State defeated Furman 73-68. Meanwhile, Virginia Tech topped Old Dominion 75-71 as it advanced to the next round. 

Tip-off from the TD Arena in Charleston, S.C. is set for noon ET. Caesars Sportsbook lists the Hokies as 1.5-point favorites in the latest Virginia Tech vs. Penn State odds from Caesars Sportsbook, while the over/under for total points scored is 139. Before making any Penn State vs. Virginia Tech picks, be sure to see the college basketball predictions and betting advice from SportsLine's proven computer model

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated an impressive profit of more than $1,200 for $100 players on its top-rated college basketball picks against the spread. 

Now, the model has set its sights on Virginia Tech vs. Penn State and just locked in its picks and CBB predictions. You can visit SportsLine now to see the picks. Here are the college basketball odds and betting lines for Penn State vs. Virginia Tech:

  • Virginia Tech vs. Penn State spread: Virginia Tech -1.5
  • Virginia Tech vs. Penn State over/under: 139 points
  • Virginia Tech vs. Penn State money line: Virginia Tech -125, Penn State +105
  • PSU: Nittany Lions are 5-0-1 ATS in their last 6 games following an ATS win
  • VT: Hokies are 12-4 ATS in their last 16 Friday games
  • Virginia Tech vs. Penn State picks: See picks at SportsLine

Why Penn State can cover 

Senior guard Jalen Pickett is having a solid start to the season. Pickett has been doing it all for the Nittany Lions, showcasing his smooth shooting stroke and stout playmaking skills. The New York native shoots well off the dribble and scans the court to find the open man. Pickett is averaging 15.8 points, 5.5 rebounds and 8.5 assists per game. He's also shooting 43% from 3-point land.

Senior guard Camren Wynter is another scoring threat in the backcourt. Wynter owns a good rotation on his jump shot and has ultimate confidence when he lets it fly. The New York native is also an active defender and looks to get into passing lanes. He is putting up 11.3 points, 3.3 rebounds, three assists and is knocking down 45% of his shots from downtown. 

Why Virginia Tech can cover

Senior forward Justyn Mutts provides the Hokies with an athletic and versatile player down low. Mutts will produce hustle plays and make solid reads as a playmaker. He can move fairly well on the court and score off the dribble at times. Mutts is averaging 9.7 points, eight rebounds and 4.3 assists per game. On Nov. 10, he logged 16 points, 11 rebounds and five assists.

Senior Hunter Cattoor is a sweet-shooting guard in the backcourt for the Hokies. Cattoor can space the floor and be a solid threat on the perimeter. The Florida native excels in catch-and-shoot situations, knocking down 47% of shots from downtown. Cattoor averages 11 points and 2.3 assists per game

How to make Virginia Tech vs. Penn State picks

SportsLine's model is leaning Over on the total, projecting 144 combined points. The model also says one side of the spread hits in almost 60% of simulations. You can see the picks here.

So who wins Penn State vs. Virginia Tech? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.