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The No. 14 Houston Cougars (24-4) host the Cincinnati Bearcats (17-12) in an American Athletic matchup at 9 p.m. ET on Tuesday, March 1 at Fertitta Center. Houston extended its winning streak to four games with a 75-61 win over SMU on Sunday, while Cincinnati saw its losing streak get extended to three games when it fell to South Florida 56-54. 

Houston is favored by 15 points in the latest Houston vs. Cincinnati odds from Caesars Sportsbook, and the over-under is set at 135.5. Before making any Cincinnati vs. Houston picks, you need to see the college basketball predictions and betting advice from the red-hot computer simulation model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,700 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Houston vs. Cincinnati, and just locked in its picks and CBB predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and betting advice for Houston vs. Cincinnati:

  • Houston vs. Cincinnati spread: Houston -15
  • Houston vs. Cincinnati over-under: 136 points
Featured Game | Houston Cougars vs. Cincinnati Bearcats

What you need to know about Houston

Houston didn't have too much trouble with the SMU Mustangs at home on Sunday as they won 75-61. Among those leading the charge for Houston was forward Fabian White Jr., who had 21 points along with nine rebounds and three blocks.

Houston is an elite defensive team, holding its opponents to a field goal percentage of 36.80%, which is tops in college basketball. The Cougars have their sights set on locking up a top seed in the upcoming NCAA Tournament, and will undoubtedly be looking to close out the regular season strong. Kyler Edwards guides Houston, averaging 13.6 points, 5.9 rebounds, and 2.9 assists per game. The Cougars are 17-11 against the spread in 2021-22.

What you need to know about Cincinnati

Meanwhile, it was close but no cigar for Cincinnati as they fell 56-54 to the South Florida Bulls this past Saturday. Guard David DeJulius had a pretty forgettable game, finishing with only seven points on 2-for-10 shooting in his 31 minutes on the court.

The Bearcats have been streaky this season, and are in the midst of a rough patch, with losses in five of their last six games. Cincinnati has been fairly consistent on the defensive end, however, holding their opponents to a field goal percentage of 39.90%, which places them 24th in college basketball. DeJulius leads the way for the Bearcats, averaging 14.4 points, 2.8 rebounds, and 2.5 assists per game. Cincinnati is 9-16-3 against the spread in 2021-22.  

How to make Houston vs. Cincinnati picks

The model has simulated Houston vs. Cincinnati 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the model's Houston vs. Cincinnati pick at SportsLine.

So who wins Cincinnati vs. Houston? And which side of the spread hits well over 50 percent of the time? Visit SportsLine to see which side of the Cincinnati vs. Houston spread to jump on, all from the advanced model that is up over $1,700 on its college basketball picks the last five-plus years, and find out.