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Group C at the 2022 FIFA World Cup is suddenly wide open, and Argentina and Mexico will both be desperate for a result when they meet Saturday at Lusail Stadium. Argentina's stunning 2-1 loss to Saudi Arabia on Tuesday upended the group, with La Albiceleste the clear favorites to win it. Now, they are in last place after Mexico and Poland played to a 0-0 draw later in the day. Lionel Messi and Co. controlled Tuesday's match but yielded two second-half goals after a Messi penalty kick sent them into halftime with the lead. El Tri needed a clutch save from iconic goalkeeper Guillermo Ochoa on a penalty from world-class striker Robert Lewandowski in the second half to secure a point from their opener. Argentina are two-time World Cup champions (1978 and 1986) and have played in all 21 World Cups. 

Kickoff is set for 2 p.m. ET in Lusail, Qatar, just outside Doha. Argentina are -210 favorites (risk $210 to win $100) on the money line in the latest Argentina vs. Mexico odds from Caesars Sportsbook, and Mexico are +700 underdogs. A draw is priced at +285 and the over/under for total match goals is listed at 2.5. Before making any Mexico vs. Argentina picks, make sure you check out the 2022 FIFA World Cup predictions, best bets and analysis from soccer insider Jon Eimer

Eimer is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, Eimer has covered the English Premier League, Serie A, the FA Cup and much more. He is an impressive 48-25-1 on his Premier League picks for SportsLine in 2022, for a profit of almost $1,800 for $100 bettors. He also went 20-12 on his World Cup qualifying picks, for a return of almost $600.

Now, Eimer has broken down Argentina vs Mexico from every angle and just revealed his 2022 World Cup picks and predictions. You can head to SportsLine now to see his picks. Here are the betting lines and trends for Mexico vs. Argentina:

  • Argentina vs. Mexico spread: Argentina -1.5 (+150)
  • Argentina vs. Mexico over/under: 2.5 goals
  • Argentina vs. Mexico money line: Argentina -210, Mexico +700, Draw +285
  • ARG: They outscored opponents 27-8 in qualifying (17 matches)
  • MEX: They had a 17-8 goal advantage in qualifying (14 matches)
  • Argentina vs. Mexico picks: See picks here

Why you should back Argentina 

La Albiceleste can't afford another slip-up, and they certainly have the talent to recover. They came into the tournament on a 36-game unbeaten run, just one short of the all-time record. Now, Messi faces a ton of pressure to produce again. The seven-time Ballon d'Or winner is Argentina's all-time top goal-scorer, and he netted his 65th on a penalty against Saudi Arabia. He is second in the sport's history with 767 goals and is an 11-time club champion. The team earned its first major international trophy of Messi's career when it went to Rio and knocked off Brazil 1-0 in the 2021 Copa America final.

Angel Di Maria scored the winning goal in that match, and he also is nearing the end of his career as a top playmaker. The 34-year-old has 27 international goals and is a dangerous option on set pieces. Lautaro Martinez brings some youthful talent to the equation, and the 25-year-old has five goals in the past five international games to give him 21 in 41 matches. Crafty midfielders Leandro Paredes, Rodrigo De Paul and Giovani Lo Celso should hold possession until they find an opening, and Messi can usually create one. Messi had 10 goals in four friendly matches before Tuesday's loss.

Why you should back Mexico

Ochoa's heroics Tuesday were nothing new to fans of El Tri, as the 37-year-old has been an integral part of the team for more than a decade. He has a 73.3 career save percentage in 20 club seasons and has 39 clean sheets over the past three-plus seasons with Club America. He is among many standouts from Mexico's Liga MX who are stars for the national team. Henry Martin has 51 goals in six seasons with Club America and Alexis Vega has 21 goals and 20 assists in five with Chivas Guadalajara, They play up top with Hirving Lozano, a 27-year-old winger for Napoli in Italy's Serie A.

Lozano was the main catalyst in Tuesday's match as El Tri held the ball for 61% of the match and outshot Poland 11-6. His agility and cleverness on the ball can cause problems for defenders, and Argentina's back line had some breakdowns in their loss. It was Lozano's goal that put Mexico past Germany 1-0 and helped eliminate the reigning champs in the group stage at the 2018 World Cup. El Tri have a ton of experience, with 10 players boasting at least 50 caps, and many have been on this stage before. It will be the Argentines who are facing the greatest pressure on Saturday.

How to make Argentina vs. Mexico picks

Eimer has taken an in-depth look at Mexico vs. Argentina. He is leaning Over on the goal total and has two other confident best bets and a full breakdown of this Group C match. He's only sharing those picks at SportsLine.

So where does all the betting value lie for Mexico vs. Argentina in Saturday's 2022 FIFA World Cup matchup? Visit SportsLine now to see the best bets for Argentina vs. Mexico, all from the soccer expert who went 20-12 on his World Cup qualifying picks, and find out.