The West Virginia Mountaineers and the No. 11 Iowa State Cyclones will face off in a Big 12 clash at 7 p.m. ET on Wednesday at WVU Coliseum. The Mountaineers are 14-9 overall and 10-3 at home, while Iowa State is 16-6 overall and 2-5 on the road. The Mountaineers have won and covered two of the last three head-to-head meetings between these two teams. 

The Mountaineers are favored by 3.5 points in the latest West Virginia vs. Iowa State odds from Caesars Sportsbook, and the over/under is set at 135.5. Before entering any Iowa State vs. West Virginia picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 13 of the season 50-29 on all top-rated college basketball picks, returning more than $1,200 for $100 players. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on West Virginia vs. Iowa State. You can head to SportsLine to see its picks. Here are several college basketball odds for West Virginia vs. Iowa State:

  • West Virginia vs. Iowa State spread: West Virginia -3.5
  • West Virginia vs. Iowa State over/under: 135.5 points
  • West Virginia vs. Iowa State money line: West Virginia -180, Iowa State +152
  • West Virginia vs. Iowa State picks: See picks here
Featured Game | West Virginia Mountaineers vs. Iowa State Cyclones

What you need to know about West Virginia

West Virginia took its contest at home this past Saturday with ease, bagging a 93-61 victory over the Oklahoma Sooners. Guard Erik Stevenson was the offensive standout of the matchup for West Virginia, shooting 6-for-11 from beyond the arc and finishing with 34 points and six rebounds.

Now playing for his fourth school in five years, Stevenson is averaging 14.9 points per game to lead the Mountaineers. But West Virginia also has four other players averaging at least 9.1 points per game, so it's a balanced and versatile offensive attack.

What you need to know about Iowa State

Meanwhile, Iowa State strolled past the Kansas Jayhawks with points to spare this past Saturday, taking the game 68-53. Iowa State's guard Tamin Lipsey was one of the most active players for the squad, racking up nine points, 10 assists and eight rebounds.

Jaren Holmes led the Cyclones with 15 points in the victory and the St. Bonaventure transfer has proven that his skills translate to a higher level. He leads the team with 13.6 points per game, while Gabe Kalscheur (13.2 ppg) and Caleb Grill (10.7 ppg) also average in double-figures.

How to make Iowa State vs. West Virginia picks

The model has simulated West Virginia vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning Over and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins West Virginia vs. Iowa State? And which side of the spread is hitting well over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is 57-37 on its top-rated college basketball picks this season, and find out.