Caleb Fuller had 16 points and eight rebounds for the seventh-seeded Aggies (13-10). Elijah Pepper added 14 points and nine rebounds.
Trevon Taylor had 20 points and eight rebounds for the Mustangs (7-21). Camren Pierce added 11 points. Brantly Stevenson had seven rebounds.
Alimamy Koroma, who led the 10th-seeded Mustangs in scoring heading into the matchup at 14 points per game, scored two points on 1-of-7 shooting.
Cal Poly advances to play No. 2 seed CSU Fullerton in a quarterfinal match-up on Thursday
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