Several of college basketball's most decorated programs will head to New Orleans on Saturday for the 2022 NCAA Tournament Final Four. The 2022 March Madness Final Four features Duke vs. North Carolina and Villanova vs. Kansas. It's the first time in NCAA Tournament history that all Final Four teams have multiple championships. North Carolina has six national titles, while Duke (five), Villanova (three) and Kansas (three) will try to close the gap.

The 2022 Final Four odds from Caesars Sportsbook list the Jayhawks as 4.5-point favorites against Villanova. Meanwhile, the Tar Heels are four-point underdogs against Duke. All of the 2022 NCAA Tournament lines for the 2022 March Madness Final Four are listed below, and SportsLine's advanced computer model has all the college basketball betting advice and predictions you need to make the best Final Four picks now.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

The model absolutely crushed its March Madness picks last tournament, beating over 92 percent of all CBS Sports brackets for the second time in three years. The model also nailed a whopping three teams in the Final Four last year. 

Now, it has turned its attention to the latest 2022 NCAA Tournament odds and locked in picks for every Final Four matchup. Head to SportsLine now to see every pick.

Top 2022 NCAA Tournament Final Four predictions

One of the model's strongest Final Four picks is that the over hits in Kansas vs. Villanova. The Jayhawks enter Saturday's showdown averaging 78.3 points per game, which ranks 23rd in the nation. Kansas is led by Ochai Agbaji, who's averaging 18.9 points and 5.2 rebounds per game. The senior guard is coming off a productive performance against the Miami Hurricanes, recording 18 points, five rebounds and four assists. The Jayhawks are knocking down 47.78 percent of their field goals this season, which ranks 21st in college basketball.

Villanova, meanwhile, is one of the best three-point shooting teams in the country, averaging 9.2 three-point field goals per game. Guard Collin Gillespie leads the Wildcats in scoring, producing 15.6 points per game. He's also been lethal from behind the arc, making over 40 percent of his three-point attempts this season. SportsLine's model has these teams combining for 145 points, which is why the over is hitting in 80 percent of simulations.

How to make 2022 March Madness picks

The model has also made the call on who will win and cover in both 2022 NCAA Tournament Final Four matchups. It has strong picks against the spread, saying one team covers 60 percent of the time. You can only get every pick for both games at SportsLine.

So which NCAA Tournament picks can you make with confidence, and which team covers the spread almost 60 percent of the time? Check out the latest Final Four odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has crushed its college basketball picks, and find out.

NCAA Tournament 2022 Final Four odds, spreads, lines

Kansas vs. Villanova (+4.5, 134)
Duke vs. North Carolina (+4, 151)