The No. 3 Houston Cougars will take on the Saint Joseph's Hawks at 6 p.m. ET Friday at Alumni Hall. This matchup is part of the 2022 Veterans Classic in Annapolis, Md., on CBS Sports Network. This is the season opener for the Hawks. Houston is 1-0 after dominating Northern Colorado 83-36 on Monday.

The Cougars are favored by 22 points in the latest Saint Joseph's vs. Houston odds from Caesars Sportsbook, and the over/under is set at 132. Before entering any Houston vs. Saint Joseph's picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated an impressive profit of more than $1,200 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Saint Joseph's vs. Houston. You can head to SportsLine to see its picks. Here are several college basketball odds for Houston vs. Saint Joseph's:

  • Saint Joseph's vs. Houston spread: Houston -22
  • Saint Joseph's vs. Houston over/under: 132 points
  • Saint Joseph's vs. Houston money line: Saint Joseph's 1600, Houston -7000
  • Saint Joseph's vs. Houston picks: See picks here
Featured Game | Saint Joseph's Hawks vs. Houston Cougars

What to know about Saint Joseph's 

Saint Joseph's struggled last year, ending up 11-19. It was the fourth straight losing season for Saint Joseph's, a program that made NCAA Tournament appearances in 2014 and 2016. Jordan Hall and Taylor Funk were Saint Joseph's top scorers last year, but they've both moved on. Hall is with the San Antonio Spurs, while Funk transferred to Utah State.

SportsLine's model is projecting that Erik Reynolds II, Cameron Brown and Ejike Obinna will be the leading scorers for the Hawks in this one. Obinna is projected to be the leading rebounder. 

What you need to know about Houston 

The Cougars have become a force in college hoops recently. They've finished no lower than No. 22 in the AP Poll every season since 2017-18 and they've done a lot of damage in the NCAA Tournament during that span, including making a Final Four run in 2021. 

Multiple key pieces such as Kyler Edwards and Fabian White are gone. But Houston gets Marcus Sasser back this year after his 2021-22 campaign ended last December due to a toe injury. Sasser scored 21 points in the opener against Northern Colorado, while forward J'Wan Roberts and guard Emanuel Sharp also hit double figures. Forward Jarace Walker opened the year with eight points, 12 rebounds and a blocked shot.

How to make Saint Joseph's vs. Houston picks

The model has simulated Saint Joseph's vs. Houston 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the pick at SportsLine.

So who will win Houston vs. Saint Joseph's? And which side of the spread is hitting in well over 60% of simulations? Visit SportsLine now to find out, all from the model that simulates each game 10,000 times