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Mike Krzyzewski and the Duke Blue Devils face lofty expectations as they open the 2022 NCAA Tournament on Friday. Duke won its first ACC regular season title since 2010, and the Blue Devils are the No. 2 seed in the West Region after winning 14 of their last 17 games. Duke takes on the No. 15 seed Cal State Fullerton Titans to open its 2022 NCAA Tournament. The Titans are the Big West Tournament champions and have won seven of their last nine contests. 

Tip-off in Greenville, South Carolina is set for 7:10 p.m. ET. The Blue Devils are 18.5-point favorites in the latest Duke vs. Cal State Fullerton odds from Caesars Sportsbook, while the over-under for total points scored is 145. Before making any Cal State Fullerton vs. Duke picks, be sure to see the college basketball predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Duke vs. Cal State Fullerton and revealed its coveted picks and predictions for the NCAA Tournament 2022. You can head to SportsLine to see the picks. Here are several college basketball odds and trends for Cal State Fullerton vs. Duke:

  • Duke vs. Cal State Fullerton spread: Duke -18.5
  • Duke vs. Cal State Fullerton over-under: 145 points
  • Duke vs. Cal State Fullerton money line: Duke -7000, CSF +1600
  • DUKE: The Blue Devils are 1-4 against the spread in their last five games
  • CSF: The Titans are 2-4 ATS in their last six games

Why Duke can cover

Duke put together an impressive resume this season. The Blue Devils beat Gonzaga, Kentucky and North Carolina, while finishing 16-4 in ACC play. The Blue Devils feature one of the nation's most explosive offenses, averaging 80.2 points per game, which ranks ninth in college basketball. 

Coach K's team is led by freshman Paolo Banchero, who's scoring 17.0 points per game. The 6'10" forward is also averaging 7.8 rebounds and 3.1 assists per game, while knocking down 47.4 percent of his field goals. He's been unstoppable in recent weeks, scoring 20 or more points in four of his last six outings. Banchero has also recorded a double-double in two of his last three games. 

Why Cal State Fullerton can cover

The underdog role seems to suit the Titans, who are 5-1 against the spread in their last six games when playing as the underdog. Cal State Fullerton beat Long Beach State, the No. 1 seed, in the Big West Tournament championship game. E.J. Anosike paced the Titans in scoring in the win, finishing with 22 points, eight rebounds and two assists. 

For the season, Anosike is averaging 16.5 points and 8.3 rebounds per game. He's making 51.8 percent of his field goals, and he's scored 16 or more points in each of his last eight outings. That includes a superb showing in Cal State Fullerton's victory over UC Davis on March 10, a game in which he recorded 16 points and 20 rebounds. 

How to make Cal State Fullerton vs. Duke picks

SportsLine's model is leaning over on the point total, projecting the teams to combine for 147 points. The model also says one side of the spread hits well over 60 percent of the time. You can only see the model's pick at SportsLine.

So who wins Duke vs. Cal State Fullerton? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.