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The San Francisco 49ers were among the Super Bowl favorites heading into the season, but they find themselves below the .500 mark heading into their matchup against Buffalo during the Week 13 NFL schedule. San Francisco is on a two-game losing skid following its 38-10 loss at Green Bay last week, and the 49ers are 6.5-point road underdogs for Sunday's matchup in the Week 13 NFL odds. Buffalo has the second-best record in the AFC behind Kansas City, along with owning the head-to-head tiebreaker over the Chiefs. Should you back the Bills to win by at least one touchdown with your Week 13 NFL bets in Buffalo, where a lake effect snow warning is in effect?

Other pivotal matchups this weekend include Bengals (-3, 46.5) vs. Steelers, Vikings (-3.5, 45) vs. Cardinals, and Ravens (-3, 51) vs. Eagles. The schedule concludes when the surging Broncos host the Browns as six-point favorites on Monday Night Football. Before locking in any Week 13 NFL picks or prop bets, be sure to check out the Week 13 NFL best bets and predictions from SportsLine's red-hot Vegas experts. 

SportsLine has more than 40 hand-picked Vegas experts who excel in multiple spots. The NFL, however, is a strength for the site as SportsLine currently has five total experts who are on NFL runs that have returned $1,400 or more for $100 players and one who has returned more than $2,400. Anybody following has seen huge returns. 

Now, with the Week 13 NFL schedule quickly approaching, SportsLine's top NFL experts are already locking in their picks. Go to SportsLine to see them all now. 

Top Week 13 NFL expert picks from R.J. White

White is a Fantasy and gambling editor for CBS Sports, consistently crushing against-the-spread picks by going 643-543-34 on his ATS betting picks from 2017-23, which returned more than $4,600 to $100 players. He also went 101-84-4 (+1366) on all NFL spread picks last season. White is on another hot streak entering Week 13, going 21-10-1 in his last 32 NFL ATS picks. 

He is backing the Bengals (-3, 46.5) to cover the spread against the Steelers in an AFC North battle. Cincinnati is coming off a critical bye week and is desperate to get back on track against a division rival. White is also backing a road underdog against a team that is dealing with multiple key injuries. See the rest of White's picks here.

Top Week 13 expert NFL picks from Larry Hartstein

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. Hartstein's weekly Vegas contest selections form the basis of his NFL best bets column, which is 79-48-2 (62.2%, +25.95 units) since its inception in 2022. Additionally, he is 74-41 in his last 115 NFL prop picks (+2434). 

Hartstein is backing the Seahawks (-105) to beat the Jets on Sunday. He notes that the Seahawks have been shutting down opposing rushing attacks in recent weeks, which will make life difficult for Jets quarterback Aaron Rodgers. Seattle has been excellent on the road this season, giving Hartstein multiple reasons to back the Seahawks against the struggling Jets. Hartstein is also backing another small favorite in a game where he thinks the line will move before kickoff. You can see Hartstein's pick for that game and others here. 

Top Week 13 NFL expert picks from Jason La Canfora

La Canfora has been covering the NFL since 2004 and spent 10 years as CBS's NFL Insider for "THE NFL TODAY" and across all platforms. He continues to cover the NFL as an analyst and insider for The Washington Post and gather information from a plethora of sources throughout the game. La Canfora is 16-9-1 in his last 26 NFL picks and has already locked in picks for multiple games throughout the weekend. 

One team that La Canfora is high on is Tampa Bay, which is a 6.5-point road favorite against Carolina in a game with an over-under of 46.5. The Buccaneers are 12-2 against-the-spread in their last 14 road games, covering by more than a touchdown on average. Carolina has eight losses by at least six points this season, and Tampa Bay has covered in four of its last five road games against the Panthers. La Canfora is also backing the Over in one of the biggest games of the week. See all of La Canfora's picks here. 

Top Week 13 NFL expert picks from Jeff Hochman

Hochman emerged on the sports betting scene in the 1990s. Today he's one of the nation's most respected and selective handicappers. Hochman dominates multiple sports. In fact, he is 45-25-2 (plus $2,343 for $100 players, every bet one unit) over the past two NFL seasons and 38-26 (plus $738) over the past two college football seasons. He enters Week 13 on an 8-6 run across his last 14 NFL picks. 

The selective expert has already placed his bet for Sunday's game between the Titans and Commanders (-6, 44.5). Washington is on a three-game losing streak and is coming off a 34-26 loss to the Cowboys, while Tennessee upset Houston last week but has been one of the worst teams in the NFL this season. Hochman's model says the spread is off by multiple points due to several factors. You can find all of Hochman's picks here.

How to make Week 13 NFL against the spread picks

SportsLine's team of experts also includes Sia Nejad, a trial attorney turned analyst who is on a 38-21 run on NFL picks. He specializes in the DFS and prop markets, and his dynamic approach to NFL betting is available only to SportsLine subscribers. This week, he's locked in a bet on a team that has a major motivational edge. Anyone who backs this team could hit it big. You can find out who his NFL picks are this weekend here. 

If you are looking for NFL picks, NFL props, or NFL best bets for Week 13, SportsLine has you covered with its proven team of experts. Visit SportsLine now to see who which teams you should back in Week 13, all from a staff that includes five experts who are on NFL runs that have returned $1,400 or more for $100 players.