Detroit Lions multi-talented WR Calvin Johnson will be a chore for the Indianapolis Colts to contain. (US Presswire)

The Colts have been thin at corner all year, and never moreso than the last few weeks. First, starting corner Jerraud Powers was placed on injured reserve. Powers, the Colts' best cover guy, was joined on the injury report by fellow starter Vontae Davis, who went down with a sprained knee.

If ever there were a bad time to be short in your defensive secondary it's when you're about to face Matt Stafford and Calvin Johnson.

Johnson's the more immediate concern. 

“When we went to his workout when he was coming out, you had seen a little bit of each in a different guy. Plaxico (Burress) was big, some guys are fast, Steve Smith’s got great hands," interim coach Bruce Arians said of Johnson. "This guy has got it all and he’s got an unbelievable work ethic. I think the most impressive thing for me was watching him block at Georgia Tech. They didn’t throw that much and he was a devastating blocker for them. Just watching him grow as a wide receiver now speaks volumes for his work ethic.”

For his part, cornerback Darius Butler understands the challenge ahead of him and the Indianapolis secondary.

“He brings everything," Butler said of Johnson. "If you want to go create a receiver on Madden, that’s going to look like Calvin Johnson. He brings everything to the table, so we are going to have to bring our ‘A’ game.”

And with regard to Davis, Arians said that he would try to practice Wednesday, but even if he plays Sunday, he won't be matched up with Johnson. That means equal time for Davis and Butler.

"We’ll play our positions. Had Vontae been healthy for the last five or six weeks ... but to put him out there coming off an injury and say, ‘Go guard Calvin,’ that’s not fair to him," Arians said. "Our guys are used to playing right and left and staying on their sides. Greg [Manusky] will do a good job as far as our coverages and trying to handle him because he is an unbelievable challenge.”

DTs Josh Chapman and Fili Moala done for the year. Both Chapman (knee) and Moala (knee) have been lost for the season, the Colts announced Monday. Moala had been a force in the middle, but he tore his ACL last week against the Bills. Chapman hadn't played all season. Indy will now look to Ricardo Mathews and Clifton Geathers to fill the middle.

Pagano taking his medicine. Head coach Chuck Pagano was doing well enough last week to watch the Colts defeat the Bills in person. And, to Arians, watching the Colts succeed is the best medicine for Pagano.

“It’s unbelievable medicine," Arians said. "Being around football I think is one of the things that’s getting him well. The more he can be in the building and be around the guys when it’s not detrimental to his health, it’s unbelievable medicine for him... You have to have a reason to want to get well, and when you have one as strong as this, it’s great medicine.”

For more up-to-the-minute news and analysis from Colts blogger Evan Hilbert, follow @CBSColts.