The San Francisco 49ers and New York Giants are two of the preeminent franchises in the NFL and will meet on Thursday Night Football in Week 3. The game will kick off at 8:15 p.m. ET from Levi's Stadium and there are already hundreds of NFL player props available for NFL prop bettors. Daniel Jones has rushed for 102 yards in his first two games and he could be in for even more rushing work on Thursday with Saquon Barkley out due to an ankle injury. Yet the latest Giants vs. 49ers props list Jones' over/under for total rushing yards at just 35.5.

Will the 49ers key in on Jones without Barkley or is this an opportunity to capitalize on as you place your NFL prop bets? Before betting any NFL props for Thursday Night Football in Week 3 or entering selections on sites like PrizePicks, you need to see the 49ers vs. Giants NFL prop predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each player prop. The AI predictions are determined by statistically learning from each player's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an over bet if a player is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last week, SportsLine AI went an astounding 19-9 on its 5-star prop picks and it is 105-70 for a $1,592 profit on 4.5 and 5-star prop predictions for the season.

For 49ers vs. Giants on Thursday Night Football, the model has evaluated the NFL player prop odds and provided Giants vs. 49ers prop picks for every available prop market. You can only see the AI player prop predictions for San Francisco vs. New York here.

Top NFL player prop bets for 49ers vs. Giants

After analyzing Giants vs. 49ers and examining the dozens of player prop markets, SportsLine AI says 49ers running back Christian McCaffrey soars past his over/under for total rushing yards of 78.5. After missing 23 games in a two-season span, McCaffrey was healthy in 2022 and was traded to the 49ers.

Since taking over as the San Francisco starter, McCaffrey has rushed for 976 yards and eight touchdowns while catching 56 passes for 476 yards and four more scores in 12 games. He's topped 78.5 rushing yards in seven of his last 10 games including the playoffs, topping the 100-yard mark in five of his last seven regular-season starts.

Now, McCaffrey will take on a Giants defense that ranked 31st in the NFL in yards allowed per carry (5.2) last season and that ranks 26th in the NFL in run defense through two games. SportsLine AI predicts another massive night for McCaffrey on Thursday, projecting he rushes for 129 yards and giving Over 78.5 rushing yards a coveted 5-star rating after going 19-9 to profit $830 on 5-star picks in Week 2. See more NFL props here.

How to make NFL player prop bets for New York vs. San Francisco

In addition, SportsLine AI says another star sails past his total and has seven other NFL props rated four stars or better. You need to see the model's analysis before making any 49ers vs. Giants prop bets for Thursday Night Football.

Which Giants vs. 49ers prop bets should you target for Thursday Night Football? Visit SportsLine now to see the top 49ers vs. Giants props, all from the brand-new SportsLine AI that went 19-9 on all 5-star rated NFL prop picks in Week 2.