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TORONTO (AP) Shohei Ohtani hit his major league-leading 39th home run for the Angels before leaving with leg cramps as the Toronto Blue Jays slugged three solo homers and rallied to beat Los Angeles 4-1 on Friday night.

Ohtani was replaced by pinch-hitter Michael Stefanic when his at-bat came up with the bases loaded in the ninth inning. Ohtani was lifted because of cramping in both of his calves, Angels manager Phil Nevin said.

“We’ll evaluate it tomorrow when he gets up,” Nevin said. “It’s just cramping right now. It’s kind of in both legs. He’s done a lot of work the last two days and wasn’t able to go.”

A day earlier, Ohtani left the second game of a doubleheader at Detroit because of cramps. The two-way superstar threw a one-hitter in the opener Thursday for his first career MLB shutout, then homered twice in the second game.

Nevin said Ohtani’s soreness developed after he grounded out to begin the eighth.

“He came in and was trying to get some work done and just kept cramping up,” Nevin said.

Stefanic struck out looking at a 3-2 pitch from right-hander Jordan Romano as Toronto ended the Angels’ four-game winning streak.

After the game, an angry Nevin was seen holding up a tablet computer and yelling at plate umpire Mike Estabrook as the crew left the field.

“I just explained to him that I thought the pitch to Stefanic was outside,” Nevin said.

Matt Chapman, Danny Jansen and Whit Merrifield homered for the Blue Jays, who are 24-11 when they hit two or more home runs.

“Our team has been playing a good brand of baseball for a while now,” Chapman said. “I think maybe we’re just starting to find ways to come out on top of some of those close games.”

Chapman hit a two-out drive in the second, his 14th of the season. Jansen homered to lead off the third, his 14th. Both home runs came off right-hander Lucas Giolito, who made his first start for the Angels since being acquired from the White Sox earlier this week.

Giolito (6-7) allowed three runs and six hits in 5 1/3 innings. He walked one and struck out five.

“I felt relatively sharp, throwing a lot of strikes, but they hammered my mistakes pretty good,” Giolito said.

Bo Bichette hit an RBI double off Giolito in the sixth and Merrifield made it 4-1 with a two-out homer off José Soriano in the seventh, his eighth. Merrifield finished 3 for 4 and has six home runs in his last 17 games. He hit a three-run homer in Thursday’s road win over the Dodgers.

The Blue Jays began the day in the third AL wild-card spot, three games ahead of the Angels. Los Angeles trails Boston and the New York Yankees in the postseason race.

After being greeted with a loud ovation from the sellout crowd of 42,106, Ohtani homered on the first pitch he faced, going deep in three straight at-bats over two games.

Ohtani’s 397-foot drive came off Blue Jays right-hander Kevin Gausman. Ohtani homered in consecutive games for the ninth time this season.

Ohtani’s streak of homers ended when he struck out swinging on a 2-2 pitch from Gausman in the third. Ohtani singled in the sixth and grounded out against left-hander Tim Mayza in the eighth.

Gausman (8-5) allowed one run and five hits in six-plus innings to win for the first time since June 21 at Miami. Gausman walked three and struck out nine, increasing his AL-leading total to 171.

Erik Swanson relieved Gausman after the Angels loaded the bases with no outs in the seventh. Swanson struck out Trey Cabbage and pinch-hitter Eduardo Escobar, then retired Luis Rengifo on a fly ball.

“Not getting one across, that hurts,” Nevin said.

Mayza worked one inning and Romano got two outs in the ninth before Yimi García finished for his third save in six chances. Romano was pitching for the fifth time since leaving the July 11 All-Star game because of a sore back.

“He’s doing alright,” manager John Schneider said of Romano. “Just lower back discomfort, it kind of locked up on him a little bit. Just kind of wanted to play it safe there.”

TRAINER’S ROOM

Angels: Before the game, Nevin said Ohtani would get an extra day of rest before his next start, which was scheduled for next Thursday’s home game against Seattle. … SS Zach Neto (sore back) was scratched from the starting lineup and replaced by Andrew Velazquez. Rengifo took over in the leadoff spot.

Blue Jays: LHP Hyun Jin Ryu (Tommy John surgery) will start on Tuesday against Baltimore, Schneider said. With the Blue Jays beginning a stretch of 17 games in 17 days Friday, Schneider said Ryu will be part of a six-man rotation. … RHP Chad Green (Tommy John surgery) will make a rehab appearance with Class-A Dunedin Saturday, his third.

ANGRY WORDS

Cameras caught Chapman yelling at Schneider in the dugout after the top of the first.

“That’s just everybody being competitive, wanting to win baseball games,” Chapman said. “Just a heat-of-the-moment kind of thing. What was said and what it’s about, I’m just going to keep between us.”

NEW-LOOK LINEUP

Blue Jays OF George Springer, who came in stuck in an 0-for-16 slump, was dropped from the leadoff spot to fifth. Springer finished 0 for 4. Merrifield moved up to hit leadoff.

ROSTER MOVES

The Angels optioned RHP Gerardo Reyes to Triple-A Salt Lake to make room on the roster for Giolito.

UP NEXT

RHP Alek Manoah (2-8, 6.10 ERA) starts for the Blue Jays on Saturday afternoon. LHP Reid Detmers (2-7, 4.38) goes for the Angels.

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