A National League Central matchup features the Milwaukee Brewers (1-0) traveling to Wrigley Field to take on the Chicago Cubs (0-1) on Saturday afternoon. The Cubs secured a 4-0 win over the Brewers on Thursday to open the regular season. In 2022, Milwaukee finished in second place in the NL Central. Meanwhile, Chicago was right behind Milwaukee in the 3rd spot. Brandon Woodruff (0-0, 0.00 ERA) gets the starting nod for Milwaukee. Justin Steele (0-0, 0.00 ERA) is on the hill for the Cubs.

First pitch is set for 2:20 p.m. ET. The Brewers are listed at -120 in the money line (risk $120 to win $100) in the latest Brewers vs. Cubs odds from Caesars Sportsbook. The over/under for total runs scored is 6.5. Before making any Cubs vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons, and it finished the 2022 MLB season on a 20-14 roll. Anybody who has followed it has seen profitable returns.

Now, the model has dialed in on Cubs vs. Brewers and revealed its predictions and best bets. You can visit SportsLine now to see the model's MLB picks. Here are the MLB odds and betting trends for Brewers vs. Cubs:

  • Brewers vs. Cubs money line: Milwaukee -120, Chicago +100
  • Brewers vs. Cubs run line: Brewers -1.5 (+143)
  • Brewers vs. Cubs over/under: 6.5 runs
  • MIL: Brewers are 4-0 in their last four during Game 2 of a series
  • CHC: Cubs are 4-0 in their last four games following an off day
  • Brewers vs. Cubs picks: See picks at SportsLine
Featured Game | Chicago Cubs vs. Milwaukee Brewers

Why you should back the Brewers 

Rookie second baseman Brice Turang is a very athletic and agile playmaker on the defensive end. Turang has good range and instincts that allow him to play freely. The California native is twitchy and can quickly drive the ball around the yard. In his MLB debut against the Chicago Cubs, he went 1-of-3 with a base hit.

Woodruff will be on the hill for the Brewers. Woodruff has a good frame with a nice rotation of pitches that includes a nasty slider. The Mississippi native likes to keep the ball low in the strike zone to produce more groundballs. In 2022, Woodruff went 13-4 with an ERA of 3.05 with 190 K's. 

Why you should back the Cubs

Shortstop Dansby Swanson joined Chicago in the offseason and provides the Cubs with a massive upgrade. Swanson has good glove skills with solid patience at the plate. The 29-year-old can spray the ball all over the field. In Thursday's affair against the Brewers, he went 3-of-4 with three base hits and one run driven in.

First baseman Trey Mancini is a very disciplined hitter with great plate coverage skills. Mancini has the power to push the ball to any part of the diamond. The 31-year-old has hammered 20-plus home runs in four of his six seasons in the league. On March 30 versus the Milwaukee Brewers, he was 1-of-3 with one single and an RBI. 

How to make Brewers vs. Cubs picks

SportsLine's model is leaning Over on the run total, as the simulations have the teams combining for 8.5 runs. It also says one side of the money line has all the value. You can only get the model's pick at SportsLine.

So who wins Cubs vs. Brewers? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model that finished last season on a roll, and find out.