Philadelphia Eagles v New York Giants
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Every NFL week starts with a Thursday Night Football game for most of the remainder of the 2021 season, and these are our favorite slates to play Daily Fantasy Football. The TNF showdown slate allows you a smaller crop of players to choose from, and if your cheap sleeper pick hits, you can cash big in your tournaments or easily win your head-to-head DFS matchups. 

Every week, I'll get the Thursday Night DFS picks from our experts and we'll feature them below. But first, let's preview the matchup and what we might expect.

The San Francisco 49ers are one of the hottest teams in the NFL and they've gotten the job done on both sides of the ball. On offense, a combination of Kyle Shanahan's system operating at a high level, Jimmy Garoppolo playing well within the system, talent at the skill positions and maybe most importantly an offensive line functioning at a high level have led to some impressive Fantasy performances -- concentrated mostly around Deebo Samuel and George Kittle. Both will be popular plays on tonight's DFS slate. A less popular play might be Bradon Aiyuk whose role has declined since Kittle's return -- both between the 20s and in the red zone.

On the flip side, the Titans offense hasn't been the same without Derrick Henry. He won't return until the NFL playoffs. However, we're still awaiting word on if the Titans' top two receivers will return for this game. Their status will swing most lineups placed tonight. Julio Jones left last week's game with an injury but has practiced this week and is expected to play tonight. For some good news, A.J. Brown is expected to return off injured reserve and he has been activated. The best advice we can give is to check back in around the time of inactives and adjust your lineups accordingly!

Without further ado, here's a look at who our experts are picking on this DFS Thursday Night Football slate:

Dave Richard

CAPTAIN/MVP Ryan Tannehill, QB, TEN
FLEX A.J. Brown, WR, TEN
FLEX Jimmy Garoppolo, QB, SF
FLEX Titans D/ST
FLEX D'Onta Foreman, RB, TEN
FLEX Geoff Swaim, TE, TEN

Jamey Eisenberg

CAPTAIN/MVP D'Onta Foreman, RB, TEN
FLEX A.J. Brown, WR, TEN
FLEX Deebo Samuel, WR, SF
FLEX Titans D/ST
FLEX Ryan Tannehill, QB, TEN
FLEX Robbie Gould, K, SF

Heath Cummings

CAPTAIN/MVP George Kittle, TE, SF
FLEX Jimmy Garoppolo, QB, SF
FLEX Brandon Aiyuk, WR, SF
FLEX D'Onta Foreman, RB, HOU
FLEX Jeff Wilson, RB, SF

Frank Stampfl

CAPTAIN/MVP Jimmy Garoppolo, QB, SF
FLEX A.J. Brown, WR, TEN
FLEX Jeff Wilson, RB, SF
FLEX George Kittle, TE, SF
FLEX Dontrelle Hilliard, RB, TEN
FLEX Geoff Swaim, TE, TEN

Chris Towers

CAPTAIN/MVP Ryan Tannehill, QB, TEN
FLEX A.J. Brown, WR, TEN
FLEX Jeff Wilson, RB, SF
FLEX Jauan Jennings, WR, SF
FLEX George Kittle, TE, SF