Sayin connected with Malone Howley for a 9-yard touchdown before hitting Justin Cayenne for a 26-yard score and Pennsylvania (4-0) grabbed a 17-7 lead after one quarter.
Sayin and Sterling Stokes hooked up for a 7-yard touchdown to push the Quakers' lead to 24-7 just 5 seconds into the second quarter.
Pierce Holley threw a 14-yard touchdown pass to Dorrien Moultrie to get Georgetown (1-5) within 10 points at halftime and Mason Gudger opened the second half with a 94-yard kickoff-return touchdown to pull the Hoyas within 24-21.
From there, Trey Flowers had touchdown runs of 1 and 38 yards and Sayin had a 2-yard touchdown run and a 23-yard scoring strike to Rory Starkey Jr. as Penn took a 52-28 lead into the final quarter. Tysen Comizio's 3-yard touchdown run in the fourth quarter capped the scoring.
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