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The No. 11 Notre Dame Fighting Irish (4-1) will aim for their fourth consecutive victory when they host the Stanford Cardinal (2-3) on Saturday afternoon. Notre Dame is wrapping up a three-game homestand following a 31-24 win over then-No. 15 Louisville. Stanford pulled off an upset as a 9-point underdog at Syracuse three weeks ago, but it has suffered blowout losses to then-No. 17 Clemson and Virginia Tech since then. These rivals have split their last 10 meetings, with Notre Dame cruising to a 56-23 road win last year. 

Kickoff is set for 3:30 p.m. ET on Saturday at Notre Dame Stadium. Notre Dame is favored by 23.5 points in the latest Notre Dame vs. Stanford odds, while the over/under is 45 points, per SportsLine consensus. Before entering any Stanford vs. Notre Dame picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks since inception, and is 8-4 on top-rated picks over the past two weeks of this season. Anyone who has followed it has seen strong returns.

The model has set its sights on Stanford vs. Notre Dame. You can head to SportsLine to see its picks. Here are several college football betting lines for the spreadmoney line and over/under:

  • Notre Dame vs. Stanford spread: Notre Dame -23.5
  • Notre Dame vs. Stanford over/under: 45.5 points
  • Notre Dame vs. Stanford money line: Notre Dame -2500, Stanford +1129
  • Notre Dame vs. Stanford picks: See picks here
  • Notre Dame vs. Stanford streaming: FuboTV (Try for free)

Why Notre Dame can cover

Notre Dame's lone loss this season was a shocking upset at home against Northern Illinois, but the Fighting Irish have looked like College Football Playoff contenders outside of that game. They have won three of their other four games by double digits, including road wins against then-No. 20 Texas A&M and Purdue. Their latest performance was a 31-24 win over then-No. 15 Louisville, covering the spread as 6.5-point favorites. 

Senior quarterback Riley Leonard completed 17 of 23 passes for 163 yards and two touchdowns against the Cardinals. He is also the team's leading rusher with 374 yards and seven touchdowns, averaging 6.3 yards per carry. The Fighting Irish are 10-2 in their last 12 home games, and they have covered the spread in six of their last eight games. See which team to pick here. 

Why Stanford can cover

Stanford is coming off back-to-back blowout losses, but it went on the road and beat Syracuse as a 9-point underdog in Week 3. Junior quarterback Ashton Daniels completed 23 of 38 passes for 178 yards in that game, while freshman running back Chris Davis Jr. added 79 yards. Daniels suffered a lower-body injury in the loss to Clemson, which caused him to miss the Virginia Tech game. 

He was questionable heading into that contest and could return this week. Freshman running back Micah Ford leads Stanford's rushing attack with 223 yards on 46 carries, racking up 122 of those yards at Clemson. Notre Dame has failed to cover the spread in both of its games as a double-digit favorite this season. See which team to pick here. 

How to make Notre Dame vs. Stanford picks

The model has simulated Stanford vs. Notre Dame 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in 60% of simulations. You can only see the pick at SportsLine.

So who wins Notre Dame vs. Stanford, and which side of the spread is hitting 60% of the time? Visit SportsLine now to see which side of the Stanford vs. Notre Dame spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.