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The Michigan State Spartans will try to secure their bowl eligibility when they face the Indiana Hoosiers on Saturday afternoon. Michigan State has won three of its last four games, including a win against Rutgers last week. Indiana, meanwhile, is riding a seven-game losing skid following a blowout loss at Ohio State.  

Kickoff is set for noon ET. The Spartans are favored by 10 points in the latest Michigan State vs. Indiana odds from Caesars Sportsbook, while the over/under is set at 47.5. Before entering any Indiana vs. Michigan State picks, you'll want to see the college football predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Michigan State vs. Indiana. You can head to SportsLine to see its picks. Here are several college football odds for Michigan State vs. Indiana:

  • Michigan State vs. Indiana spread: Michigan State -10
  • Michigan State vs. Indiana over/under: 47.5 points
  • Michigan State vs. Indiana money line: Michigan State -385, Indiana +300
  • Michigan State vs. Indiana picks: See picks here
Featured Game | Michigan State Spartans vs. Indiana Hoosiers

Why Michigan State can cover

Michigan State looked like it was going to miss out on a bowl appearance in the middle of October, but the Spartans have put themselves in a position to clinch a postseason game. They have won three of their last four games, notching a win against Rutgers last week. Michigan State also pulled off a big upset at Illinois two weeks ago as a 16-point underdog. 

Quarterback Payton Thorne threw for 256 yards and two touchdowns against Rutgers, while running backs Jalen Berger and Jarek Broussard combined for 165 yards. They are facing an Indiana team that is on a seven-game losing streak and is coming off consecutive blowout losses. Michigan State has won 11 of the last 13 meetings between these teams, including eight of its last nine at home. 

Why Indiana can cover

Michigan State might be on a decent run right now, but this is still the same team that lost five out of six games earlier this year. The Spartans lost all five of those games by double digits, making them undeserving of being double-digit favorites on Saturday. Indiana took down Illinois earlier this season and also beat Western Kentucky, so it is certainly capable of beating quality teams. 

The Hoosiers have only lost two games by double digits against unranked opponents, with the most recent occurrence coming on Oct. 1. They could choose to start Dexter Williams II at quarterback, which would give them a spark. Michigan State has to face Penn State next week, putting a lot of pressure on the Spartans to get the job done on Saturday. 

How to make Indiana vs. Michigan State picks

The model has simulated Michigan State vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You can only see the pick at SportsLine.

So who wins Indiana vs. Michigan State? And which side of the spread hits in over 50% of simulations? Visit SportsLine now to see which side of the Michigan State vs. Indiana spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.