Clemson coach Dabo Swinney had won 21 straight games in Death Valley, and the Tigers had not lost a regular season game since 2014 before Pitt kicker Chris Blewitt split the uprights in the Panthers' stunning 43-42 upset on Saturday.
The Tigers were denied a chance to clinch the ACC Atlantic and now have handed their College Football Playoff chances over to the CFP Selection Committee as a one-loss team trying to rely on a conference championship to clinch one of four available spots.
The upset loss sent one Clemson fan into an absolute fit of rage, causing him to throw his remote control through the TV after the game.
Clemson's playoff future is the immediate concern for fans, but Pitt's win carries even more historical significance for the Swinney era. It's only Dabo's 16th ACC loss in 71 games, and t ends a 44-game winning streak against unranked opponents. There will be chances to regain a spot in the playoff in the next couple weeks with a win in the ACC title game, but now Clemson has to beat Wake Forest on the road next week to even secure a spot in that game.