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Coach Deion Sanders and the No. 19 Colorado Buffaloes again find themselves as three-score underdogs as they take on the No. 10 Oregon Ducks. Coach Prime opened his tenure at Colorado as a similar underdog on the road at TCU. Colorado has exceeded expectations since that point, pulling off that giant upset in Week 1 and then continuing on to a 3-0 start. Oregon, meanwhile, is 3-0 both straight up and against the spread and the Ducks are hungry to slow the Colorado hype train as they look to build their own College Football Playoff case.

Follow live updates and highlights from Colorado vs. Oregon.

Kickoff at Autzen Stadium is set for 3:30 p.m. ET. SportsLine consensus lists the Ducks at -21 in the latest Colorado vs. Oregon odds. The over/under is 70.5, down two points from the opening Colorado vs. Oregon line. Before making any Oregon vs. Colorado picks or bets, be sure to check out the college football predictions and betting advice from SportsLine football expert Jimmie Kaylor

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his Colorado picks this season, going 4-1 on his best bets in the Buffs' first three games of the season. Anyone who has followed his picks is way up.

Now, he has set his sights on Colorado vs. Oregon and just locked in its picks and CFB predictions. You can head to SportsLine now to see Kaylor's picks. Here are several college football odds and betting lines for Oregon vs. Colorado:

  • Colorado vs. Oregon spread: Oregon -21
  • Colorado vs. Oregon over/under: 70.5 points
  • Colorado vs. Oregon money line: Oregon -885, Colorado +584
  • CU: QB Shedeur Sanders is averaging 417 passing yards per game
  • ORE: The Ducks are 7-1 at Autzen Stadium with Dan Lanning as head coach and Bo Nix at QB
  • Colorado vs. Oregon picks: See picks at SportsLine
  • Colorado vs. Oregon live stream: fubo (try for free)

Why Colorado can cover

Junior quarterback Shedeur Sanders has shown enough in his first three games at Colorado to insert himself into the Heisman Trophy race. With Sanders under center the Buffs are capable of scoring in bunches, and should be competitive in every game they play. Through three weeks, Sanders has completed 78.7% of his passes for 1,251 yards, 10 touchdowns and one interception. He's also added one rushing touchdown.

The Buffs have surrounded Sanders with a bevy of explosive options to spread the ball around. Wide receivers Xavier Weaver (25 catches, 386 yards, 2 TDs) and Jimmy Horn Jr. (26 catches, 242 yards, 2 TDs), both South Florida transfers, and freshman running back Dylan Edwards (136 rushing yards, 1 TD, 14 catches, 160 receiving yards, 3 TD catches) have all flashed glimpses of elite level explosiveness in the Colorado offense. See which team to pick at SportsLine

Why Oregon can cover

Colorado has largely exceeded public and oddsmaker expectations through three weeks, but the task gets much tougher this week. Oregon is the first true title contender that Colorado has seen this season and this will be the most hostile environment as well. Led With Nix leading the offense, Oregon has put up video game-like numbers thus far, averaging 58 points per game.

One non-QB is rarely enough to impact the spread too much, but Colorado losing Travis Hunter (liver) is a massive blow. He's played nearly every snap of the season as a two-way receiver and cornerback as well as helping on special teams. He certainly would've given Colorado more of a chance to keep this one competitive. See which team to back at SportsLine

How to make Oregon vs. Colorado picks

Kaylor has analyzed this matchup from every angle and he's leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Colorado vs. Oregon in the Pac-12 debut for Deion Sanders, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Colorado vs. Oregon picks, all from the expert who has covered college football for over a decade and is 4-1 on his Colorado best bets in 2023, and find out.