College football odds, picks, predictions, best bets for Week 12: Computer likes Cincinnati, Oklahoma State

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The No. 18 Notre Dame Fighting Irish will try to continue their late-season surge when they face the Boston College Eagles during the Week 12 college football schedule. Notre Dame has rattled off four consecutive wins since losing to Stanford in mid-October. The Fighting Irish knocked off a pair of ranked teams during that stretch, and they held off Navy for a win last week. They are 20.5-point favorites in the latest Week 12 college football odds at Caesars Sportsbook.

One team that Notre Dame beat during its current winning streak was Clemson, which is a 19-point favorite against Miami (Fla.) on Saturday afternoon. Should you be backing either of those heavy favorites with your Week 12 college football bets? Before making any Week 12 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 12 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 12

One of the college picks the model is high on in Week 12: No. 25 Cincinnati (-17) covers at Temple in a 4 p.m. ET kickoff on Saturday. The Bearcats have two losses by a combined 11 points entering Saturday and Luke Fickell's squad will need to keep the pedal to the metal while locked in a tight AAC race with UCF and Tulane. All three teams are at 5-1 and with UCF holding the tiebreaker over both teams and the top two teams advancing to the AAC Championship Game.

Cincinnati narrowly escaped with a 27-25 win over East Carolina last week to move to 8-2 on the season but now the Bearcats get a much easier matchup against the Owls in Stan Drayton's first season as head coach. Temple has lost five of six and allowed at least 450 yards of total offense in four of its last five games. The model is predicting that soft defensive unit is exactly what the Cincinnati offense needs to get back on track, predicting that the Bearcats score 40 and cover nearly 70% of the time.

Another one of the Week 12 college football picks from the model: No. 22 Oklahoma State (+7.5) easily covers in its Bedlam Series rivalry game against Oklahoma on Saturday night. The Sooners have been one of the most disappointing teams in college football this season, as they are still ineligible for a bowl game with just two games remaining. They are unranked facing a ranked Oklahoma State team for just the fourth time in the history of Bedlam.

Oklahoma State recorded a 37-33 victory when these teams met last season, as quarterback Spencer Sanders accounted for more than 300 yards and two touchdowns. He is facing an Oklahoma defense that is allowing 432.3 yards per game, so this should be another big day for Sanders, who is expected to play through a shoulder injury. SportsLine's model has Sanders racking up nearly 300 yards and at least two touchdowns, as Oklahoma State is covering the spread in almost 70% of simulations. See which other teams the model likes here.

How to make college football picks for Week 12

The model has also made the call on who wins and covers in every other FBS matchup in Week 12, and it says several top-20 teams will go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-20 teams go down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past six-plus seasons, and find out.