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The Syracuse Orange will look to start the season 5-0 for the second consecutive season and third time since 1987 when they battle the Clemson Tigers in an ACC matchup on Saturday. It will be the conference opener for the Orange, who beat Army 29-16 a week ago. The Tigers (2-2, 0-2 ACC) are coming off a 31-24 overtime ACC loss to Florida State in Week 4. In Clemson's other conference matchup, the Tigers dropped a 28-7 decision at Duke in the season opener.

Kickoff from the JMA Wireless Dome in Syracuse, N.Y., is set for noon ET. The Tigers are averaging 474.3 yards per game, while the Orange average 507.8. The Tigers are favored by 7 points in the latest Clemson vs. Syracuse odds via SportsLine consensus, while the over/under for total points scored is 53. Before making any Syracuse vs. Clemson picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Syracuse and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Clemson vs. Syracuse:

  • Clemson vs. Syracuse spread: Clemson -7
  • Clemson vs. Syracuse over/under: 53 points 
  • Clemson vs. Syracuse money line: Clemson -286, Syracuse +230
  • CLE: The Tigers have hit the first-half money line in four of their last five road games 
  • SYR: The Orange have gone under game total in five of their last seven at home 
  • Clemson vs. Syracuse picks: See picks at SportsLine 
  • Clemson vs. Syracuse live stream: fubo (try for free)

Why Clemson can cover

Helping lead the offense is junior wide receiver Beaux Collins. He has a team-high 17 catches for 226 yards (13.3 average) and one touchdown. His best game came in a 66-17 win over Charleston Southern, when he caught seven passes for 137 yards (19.6 average) and a score. He is in his third season with the Tigers, catching 22 passes for 373 yards (17.0 average) and five touchdowns in 2022. For his career, he has 70 receptions for 1,006 yards (14.4 average) and nine TDs.

Defensively, junior linebacker Jeremiah Trotter Jr. leads the team with 23 tackles, including 10 solo. He also has one sack for seven yards and one forced fumble. Trotter is coming off a six tackle performance against Florida State, including a sack. Trotter was among the team leaders last season with 89 tackles, including 49 solo, with 6.5 sacks, five pass breakups, one forced fumble and two interceptions, including one he returned for a touchdown. See which team to pick here.

Why Syracuse can cover 

Also off to a fast start is running back LeQuint Allen, who is in his second season with the Orange. The sophomore has carried a team-high 61 times for 311 yards (5.1 average) and six touchdowns. He also has 11 receptions for 95 yards (8.6 average). He is coming off his second 100-plus rushing game after carrying 21 times for 104 yards and one score in the win over Army. He has scored at least one TD in each game, including three in a 48-7 win over Western Michigan on Sept. 9.

Helping power the defense is junior linebacker Marlowe Wax. He leads the team with 31 tackles, including 19 solo, with two sacks for 17 yards. He has one pass breakup and has two forced fumbles. In the 35-20 win at Purdue, he made 11 tackles, including eight solo, with one sack. In four seasons at Syracuse, he has recorded 212 tackles, including 135 solo, with 16.5 sacks, four pass breakups and seven forced fumbles. See which team to pick here.

How to make Clemson vs. Syracuse picks

SportsLine's model is leaning Under on the total, projecting 45 combined points. It has also generated an against-the-spread pick that hits in well over 50% of simulations. You can only get the model's pick at SportsLine

So who wins Clemson vs. Syracuse, and which side of the spread cashes in well over 50% of simulations? Visit SportsLine now to see which side of the Clemson vs. Syracuse spread to jump on, all from the advanced model that finished up nearly $2,500 on its FBS college football picks since its inception, and find out.