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One team's season will extend by one game, and another team's season will come to an end when the USC Upstate Spartans and Charleston Southern Buccaneers collide in a quarterfinal game of the 2022 Big South tournament on Friday afternoon at Bojangles Coliseum in Charlotte, N.C. The Buccaneers (6-24) already have pulled off an upset in the conference tournament, knocking off fifth-seeded UNC Asheville, 79-78, in the first round of the tournament on Wednesday. Meanwhile, the fourth-seeded Spartans (13-15) earned a bye into the quarterfinals. The winner will face either top-seeded Longwood or ninth-seeded North Carolina A&T on Saturday. 

Tipoff is set for 2 p.m. ET. The Spartans are favored by 5.5 points in the latest USC Upstate vs. Charleston Southern odds from Caesars Sportsbook, while the over-under for total points scored is 143. Before making any Charleston Southern vs. USC Upstate picks, you need to see the college basketball predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,700 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on USC Upstate vs. Charleston Southern, and just locked in its picks and CBB predictions. You can head to SportsLine now to see the model's picks. Now, here are several college basketball odds and betting lines for Charleston Southern vs. USC Upstate:

  • USC Upstate vs. Charleston Southern spread: Spartans -5.5
  • USC Upstate vs. Charleston Southern over-under: 143 points
  • USC Upstate vs. Charleston Southern money line: Spartans -260, Buccaneers +210
  • UPST: Bryson Mozone ranks sixth in the conference in points per game (15.2).
  • CHSO: Tahlik Chavez leads the Big South in 3-pointers per game (2.87).

Why Charleston Southern can cover

Charleston Southern has one of the conference's most dangerous shooters in Tahlik Chavez. The 6-foot-2 junior from Arlington, Texas, leads the Big South in 3-pointers per game (2.87). He also ranks fourth in the conference in 3-point field goal percentage (36.8).

In addition, Taje' Kelly is playing his best basketball of the season. In Wednesday's upset over Asheville, the 6-foot-8 freshman from Atlanta scored a career-high 24 points, including the game-winning putback at the buzzer, and seven rebounds. The performance came one game after his first career double-double.

Why USC Upstate can cover

Freshman Jordan Gainey already is one of the best players in the Big South. The 6-foot-4 guard from Tucson, Ariz., is averaging 13.4 points per game overall and 16.3 points per game in conference play while shooting more than 50.0 percent in Big South play. For his efforts this season he was named Big South Freshman of the Year and a member of the all-Big South second team.

In addition, USC Upstate faces a Charleston Southern team that has struggled mightily this season. The Buccaneers have just three wins against Division I teams versus 24 losses. They also are one of the worst teams in the country at taking care of the ball, averaging 14.6 turnover per game, which ranks 314th in the nation.

How to make USC Upstate vs. Charleston Southern picks

SportsLine's model is leaning under on the total, projecting 142 combined points. The model also says one side of the spread hits in almost 60 percent of simulations. You can only see the model's pick at SportsLine.

So who wins Charleston Southern vs. USC Upstate? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.