We've got another exciting SEC matchup on the schedule as the Mississippi State Bulldogs and the Ole Miss Rebels are set to tip at 9 p.m. ET on Wednesday at Humphrey Coliseum. Miss. State is 17-8 overall and 10-2 at home, while Ole Miss is 19-6 overall and 3-5 on the road. The Bulldogs have won four of the last six meetings against the Rebels. 

This time around, Miss. State is favored by 6.5 points in the latest Mississippi State vs. Ole Miss odds, and the over/under is 141 points. Before entering any Ole Miss vs. Mississippi State picks, you'll want to see the NCAA Basketball predictions from the advanced computer model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 16 of the 2023-24 season on a 136-89 roll on all top-rated college basketball picks dating back to last season, returning nearly $2,500 for $100 players. It is also off to a sizzling 25-13 start on top-rated spread picks this season. Anyone following has seen huge returns.

The model has set its sights on Ole Miss vs. Miss. State. You can head to SportsLine to see its picks. Here are several college basketball betting lines for the game:

  • Miss. State vs. Ole Miss spread: Miss. State -6.5
  • Miss. State vs. Ole Miss over/under: 141 points
  • Miss. State vs. Ole Miss money line: Miss. State: -303, Ole Miss: +243
  • Miss. State vs. Ole Miss picks: See picks here

What you need to know about Mississippi State

Mississippi State waltzed into its matchup on Saturday with two straight wins but the Bulldogs left with three. The Bulldogs snuck past the Arkansas Razorbacks with a 71-67 win. Cameron Matthews was the offensive standout of the match as he dropped a double-double with 17 points and 10 rebounds. For the season, Matthews is averaging 9.6 points and 7.2 rebounds per game. 

The Bulldogs have won seven of their last eight games at home. Mississippi State has also dominated Ole Miss on its home floor, winning 15 of the last 20 meetings against the Rebels at Humphrey Coliseum. 

What you need to know about Ole Miss

Meanwhile, Ole Miss came into Saturday's matchup having lost three straight, but that streak is now in the rearview. The Rebels narrowly escaped with a win as Chris Beard's squad sidled past the Missouri Tigers 79-76. 

Ole Miss can attribute much of its success to Matthew Murrell, who went 6 for 9 from beyond the arc en route to 26 points. Allen Flanigan was another key contributor, dropping a double-double with 16 points and 10 rebounds. The Rebels are scoring 76.0 points per game this season, which ranks 115th in the nation. 

How to make Mississippi State vs. Ole Miss picks

The model has simulated Miss. State vs. Ole Miss 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Ole Miss vs. Mississippi State, and which side of the spread hits well over 50% of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that is on a 136-89 roll on its top-ranked college basketball picks, and find out.